8V6U

5HT2AR-miniGq heterotrimer in complex with a novel agonist obtained from large scale docking

Summary for 8V6U

• Entry DOI: 10.2210/pdb8v6u/pdb
• EMDB information: 42999
• Descriptor: 5-hydroxytryptamine receptor 2A, G protein alpha-subunit q (Gi2-mini-Gq chimera), Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total)
• Functional Keywords: active state gpcr, heterotrimer, complex, serotonin, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 142472.79

Authors

Gumpper, R.H.,Wang, L.,Kapolka, N.,Skiniotis, G.,Roth, B.L. (deposition date: 2023-12-03, release date: 2024-05-29, Last modification date: 2024-07-03)

• Primary citation: Lyu, J.,Kapolka, N.,Gumpper, R.,Alon, A.,Wang, L.,Jain, M.K.,Barros-Alvarez, X.,Sakamoto, K.,Kim, Y.,DiBerto, J.,Kim, K.,Glenn, I.S.,Tummino, T.A.,Huang, S.,Irwin, J.J.,Tarkhanova, O.O.,Moroz, Y.,Skiniotis, G.,Kruse, A.C.,Shoichet, B.K.,Roth, B.L.; AlphaFold2 structures guide prospective ligand discovery.; Science, 384:eadn6354-eadn6354, 2024; PubMed: 38753765; DOI: 10.1126/science.adn6354

Experimental method

ELECTRON MICROSCOPY (3 Å)