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4BIO
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BU of 4bio by Molmil
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH 8-HYDROXYQUINOLINE-5- CARBOXYLIC ACID
分子名称: 8-hydroxyquinoline-5-carboxylic acid, FE (III) ION, GLYCEROL, ...
著者Chowdhury, R, Schofield, C.J.
登録日2013-04-12
公開日2013-04-24
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.
Chem Sci, 4, 2013
4AI9
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BU of 4ai9 by Molmil
JMJD2A Complexed with Daminozide
分子名称: CHLORIDE ION, DAMINOZIDE, GLYCEROL, ...
著者Chowdhury, R, Schofield, C.J.
登録日2012-02-08
公開日2012-10-03
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.
J. Med. Chem., 55, 2012
4BIS
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BU of 4bis by Molmil
JMJD2A COMPLEXED WITH 8-HYDROXYQUINOLINE-4-CARBOXYLIC ACID
分子名称: 8-hydroxyquinoline-4-carboxylic acid, CHLORIDE ION, GLYCEROL, ...
著者Chowdhury, R, Thinnes, C, Schofield, C.J.
登録日2013-04-12
公開日2014-02-05
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.493 Å)
主引用文献5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.
Chem Sci, 4, 2013
6YW1
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BU of 6yw1 by Molmil
HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with 2OG and RaPID-derived silent allosteric cyclic peptide 3C (14-mer)
分子名称: 2-OXOGLUTARIC ACID, BICARBONATE ION, Egl nine homolog 1, ...
著者Chowdhury, R, Schofield, C.J.
登録日2020-04-29
公開日2020-12-30
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.46 Å)
主引用文献Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2.
Sci Rep, 10, 2020
6YW3
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BU of 6yw3 by Molmil
HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) in complex with N-Oxalyl Glycine (NOG), HIF-1ALPHA CODD (556-574) and a RaPID-derived cyclic peptide 3C (14-mer)
分子名称: Egl nine homolog 1, GLYCEROL, Hypoxia-inducible factor 1-alpha, ...
著者Chowdhury, R, Schofield, C.J.
登録日2020-04-29
公開日2020-12-30
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.279 Å)
主引用文献Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2.
Sci Rep, 10, 2020
6YW4
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BU of 6yw4 by Molmil
HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with N-oxalylglycine (NOG) and a RaPID-derived silent allosteric cyclic peptide 3C (14-mer)
分子名称: Egl nine homolog 1, MANGANESE (II) ION, N-OXALYLGLYCINE, ...
著者Chowdhury, R, Schofield, C.J.
登録日2020-04-29
公開日2020-12-30
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.528 Å)
主引用文献Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2.
Sci Rep, 10, 2020
3U4S
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BU of 3u4s by Molmil
Histone Lysine demethylase JMJD2A in complex with T11C peptide substrate crosslinked to N-oxalyl-D-cysteine
分子名称: HISTONE 3 TAIL ANALOG (T11C Peptide), Lysine-specific demethylase 4A, N-(carboxycarbonyl)-D-cysteine, ...
著者Ma, J, McDonough, M.A, Schofield, C.J.
登録日2011-10-10
公開日2012-02-08
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Linking of 2-Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases.
Angew.Chem.Int.Ed.Engl., 51, 2012
6YW2
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BU of 6yw2 by Molmil
HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with bicyclic FG2216 and RaPID-derived cyclic peptide 3C (14-mer)
分子名称: Egl nine homolog 1, MANGANESE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ...
著者Chowdhury, R, Schofield, C.J.
登録日2020-04-29
公開日2020-12-30
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2.
Sci Rep, 10, 2020
2YBK
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BU of 2ybk by Molmil
JMJD2A COMPLEXED WITH R-2-HYDROXYGLUTARATE
分子名称: (2R)-2-hydroxypentanedioic acid, CHLORIDE ION, LYSINE-SPECIFIC DEMETHYLASE 4A, ...
著者Chowdhury, R, McDonough, M.A, Schofield, C.J.
登録日2011-03-08
公開日2011-04-06
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
EMBO Rep., 12, 2011
2YC0
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BU of 2yc0 by Molmil
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH R-2-HYDROXYGLUTARATE
分子名称: (2R)-2-hydroxypentanedioic acid, FE (II) ION, GLYCEROL, ...
著者Chowdhury, R, Clifton, I.J, Schofield, C.J.
登録日2011-03-10
公開日2011-03-30
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
EMBO Rep., 12, 2011
2YBS
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BU of 2ybs by Molmil
JMJD2A COMPLEXED WITH S-2-HYDROXYGLUTARATE AND HISTONE H3K36me3 PEPTIDE (30-41)
分子名称: (2S)-2-HYDROXYPENTANEDIOIC ACID, GLYCEROL, HISTONE H3.1T, ...
著者Chowdhury, R, Schofield, C.J.
登録日2011-03-10
公開日2011-03-30
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
EMBO Rep., 12, 2011
2YBP
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BU of 2ybp by Molmil
JMJD2A COMPLEXED WITH R-2-HYDROXYGLUTARATE AND HISTONE H3K36me3 PEPTIDE (30-41)
分子名称: (2R)-2-hydroxypentanedioic acid, GLYCEROL, HISTONE H3.1T, ...
著者Chowdhury, R, McDonough, M.A, Schofield, C.J.
登録日2011-03-09
公開日2011-03-30
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
EMBO Rep., 12, 2011
2YDE
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BU of 2yde by Molmil
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH S-2-HYDROXYGLUTARATE
分子名称: (2S)-2-HYDROXYPENTANEDIOIC ACID, FE (III) ION, GLYCEROL, ...
著者Chowdhury, R, Clifton, I.J, Schofield, C.J.
登録日2011-03-18
公開日2011-03-30
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
EMBO Rep., 12, 2011
5YJA
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BU of 5yja by Molmil
Crystal structure of highly active BTUO mutant P287G without dehydration
分子名称: 2-METHOXYETHANOL, 8-AZAXANTHINE, OXYGEN MOLECULE, ...
著者Hibi, T, Itoh, T, Nishiya, Y.
登録日2017-10-09
公開日2018-10-10
最終更新日2018-12-19
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Flexibility of a Distal Interface Loop Modulates Water Network in the Active Site of Bacillus sp. TB-90 Urate Oxidase
to be published
5Z2B
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BU of 5z2b by Molmil
Crystal structure of highly active BTUO mutant P287G Improved by Humidity Control at 86% RH
分子名称: 1,2-ETHANEDIOL, 8-AZAXANTHINE, CHLORIDE ION, ...
著者Hibi, T, Itoh, T, Nishiya, Y.
登録日2018-01-02
公開日2019-01-02
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.901 Å)
主引用文献Flexibility of a Distal Interface Loop Modulates Water Network in the Active Site of Bacillus sp. TB-90 Urate Oxidase
to be published
4C8R
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BU of 4c8r by Molmil
Human gamma-butyrobetaine dioxygenase (BBOX1) in complex with Ni(II) and N-(3-hydroxypicolinoyl)-S-(pyridin-2-ylmethyl)-L-cysteine (AR692B)
分子名称: 1,2-ETHANEDIOL, GAMMA-BUTYROBETAINE DIOXYGENASE, N-(3-hydroxypicolinoyl)-S-(pyridin-2-ylmethyl)-L-cysteine, ...
著者Chowdhury, R, Rydzik, A.M, Kochan, G.T, McDonough, M.A, Schofield, C.J.
登録日2013-10-01
公開日2014-05-14
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.82 Å)
主引用文献Modulating carnitine levels by targeting its biosynthesis pathway - selective inhibition of gamma-butyrobetaine hydroxylase.
Chem Sci, 5, 2014
5Z27
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BU of 5z27 by Molmil
Crystal structure of highly active BTUO mutant P287G without dehydration
分子名称: 1,2-ETHANEDIOL, 8-AZAXANTHINE, OXYGEN MOLECULE, ...
著者Hibi, T, Itoh, T, Nishiya, Y.
登録日2017-12-29
公開日2019-01-02
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Flexibility of a Distal Interface Loop Modulates Water Network in the Active Site of Bacillus sp. TB-90 Urate Oxidase
to be published
5Y52
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BU of 5y52 by Molmil
Crystal Structure of Highly Active BTUO Mutant P287G Improved by Humidity Control at 83% RH
分子名称: 1,2-ETHANEDIOL, 8-AZAXANTHINE, OXYGEN MOLECULE, ...
著者Itoh, T, Kishimoto, T, Nishiya, Y.
登録日2017-08-07
公開日2018-08-08
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Conformational Flexibility of Plastic Interface Loop Allows Entropic Adaptation of Urate Oxidase to Environmental pH
To Be Published
5YJ2
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BU of 5yj2 by Molmil
Crystal structure of Bacillus sp. TB-90 urate oxidase without dehydration
分子名称: 2-METHOXYETHANOL, 8-AZAXANTHINE, OXYGEN MOLECULE, ...
著者Hibi, T, Itoh, T, Nishiya, Y.
登録日2017-10-07
公開日2018-10-10
最終更新日2018-12-19
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Crystal structure of Bacillus sp. TB-90 urate oxidase without dehydration
To Be Published
5Y2P
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BU of 5y2p by Molmil
Crystal Structure of Bacillus sp. TB-90 Urate Oxidase Improved by Humidity Control at 89% RH
分子名称: 1,2-ETHANEDIOL, 8-AZAXANTHINE, OXYGEN MOLECULE, ...
著者Itoh, T, Nishiya, Y.
登録日2017-07-26
公開日2018-08-08
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Conformational Flexibility of Plastic Interface Loop Allows Entropic Adaptation of Urate Oxidase to Environmental pH.
To Be Published
5FWE
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BU of 5fwe by Molmil
JMJD2A COMPLEXED WITH NI(II), NOG AND HISTONE H4(1-15)R3me2s PEPTIDE
分子名称: CHLORIDE ION, GLYCEROL, LYSINE-SPECIFIC DEMETHYLASE 4A, ...
著者Chowdhury, R, Walport, L.J, Schofield, C.J.
登録日2016-02-15
公開日2016-04-06
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Arginine Demethylation is Catalysed by a Subset of Jmjc Histone Lysine Demethylases.
Nat.Commun., 7, 2016
5LAS
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BU of 5las by Molmil
HIF prolyl hydroxylase 2 (PHD2-R281C/P317C/R396T) cross-linked to HIF-1alpha NODD-L397C/D412C and N-oxalylglycine (NOG) (complex-3)
分子名称: Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ...
著者Chowdhury, R, Schofield, C.J.
登録日2016-06-14
公開日2016-08-31
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5LB6
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BU of 5lb6 by Molmil
HIF prolyl hydroxylase 2 (PHD2/EGLN1) R371H variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)
分子名称: Egl nine homolog 1, GLYCEROL, MANGANESE (II) ION, ...
著者Chowdhury, R, Schofield, C.J.
登録日2016-06-15
公開日2016-08-31
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5LBE
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BU of 5lbe by Molmil
HIF prolyl hydroxylase 2 (PHD2/EGLN1) G294E variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216)
分子名称: BICARBONATE ION, Egl nine homolog 1, MANGANESE (II) ION, ...
著者Chowdhury, R, Schofield, C.J.
登録日2016-06-15
公開日2016-08-31
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.749 Å)
主引用文献Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5LBC
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BU of 5lbc by Molmil
HIF prolyl hydroxylase 2 (PHD2/EGLN1) I280V/R281L/I292V variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216)
分子名称: BICARBONATE ION, CHLORIDE ION, Egl nine homolog 1, ...
著者Chowdhury, R, Schofield, C.J.
登録日2016-06-15
公開日2016-08-31
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.816 Å)
主引用文献Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016

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