4C8R
Human gamma-butyrobetaine dioxygenase (BBOX1) in complex with Ni(II) and N-(3-hydroxypicolinoyl)-S-(pyridin-2-ylmethyl)-L-cysteine (AR692B)
Summary for 4C8R
Entry DOI | 10.2210/pdb4c8r/pdb |
Descriptor | GAMMA-BUTYROBETAINE DIOXYGENASE, NICKEL (II) ION, ZINC ION, ... (6 entities in total) |
Functional Keywords | oxidoreductase, non-heme, iron, 2-oxoglutarate, dioxygenase 1, dsbh, facial triad, gamma-butyrobetaine, hydroxylase |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 6 |
Total formula weight | 272785.41 |
Authors | Chowdhury, R.,Rydzik, A.M.,Kochan, G.T.,McDonough, M.A.,Schofield, C.J. (deposition date: 2013-10-01, release date: 2014-05-14, Last modification date: 2023-12-20) |
Primary citation | Rydzik, A.M.,Chowdhury, R.,Kochan, G.T.,Williams, S.T.,McDonough, M.A.,Kawamura, A.,Schofield, C.J. Modulating carnitine levels by targeting its biosynthesis pathway - selective inhibition of gamma-butyrobetaine hydroxylase. Chem Sci, 5:1765-1771, 2014 Cited by PubMed: 26682037DOI: 10.1039/C4SC00020J PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.82 Å) |
Structure validation
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