7ZJD
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7DSS
| Complex of FMDV and M8 Nab | 分子名称: | M8 Nab, VP1 of O type FMDV capsid, VP2 of O-type FMDV capsid, ... | 著者 | Dong, H, Liu, P. | 登録日 | 2021-01-02 | 公開日 | 2021-03-31 | 最終更新日 | 2022-05-25 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structural and molecular basis for foot-and-mouth disease virus neutralization by two potent protective antibodies. Protein Cell, 13, 2022
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7DST
| FMDV capsid in complex with M170 Nab | 分子名称: | M170 Nab, VP1 of O type FMDV capsid, VP2 of O type FMDV capsid, ... | 著者 | Dong, H, Liu, P. | 登録日 | 2021-01-02 | 公開日 | 2021-03-10 | 最終更新日 | 2022-05-25 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural and molecular basis for foot-and-mouth disease virus neutralization by two potent protective antibodies. Protein Cell, 13, 2022
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7Y50
| Class I diterpene synthase (CyS) from Streptomyces cattleya | 分子名称: | Putative glutamate dehydrogenase/leucine dehydrogenase | 著者 | Xing, B, Ma, M. | 登録日 | 2022-06-16 | 公開日 | 2022-12-21 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structure Based Mutagenesis of Cattleyene Synthase Leads to the Generation of Rearranged Polycyclic Diterpenes. Angew.Chem.Int.Ed.Engl., 61, 2022
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7Y87
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7Y88
| class I diterpene synthase (CyS-GGPP-Mg2+) from Streptomyces cattleya | 分子名称: | GERANYLGERANYL DIPHOSPHATE, MAGNESIUM ION, Putative glutamate dehydrogenase/leucine dehydrogenase | 著者 | Xing, B, Ma, M. | 登録日 | 2022-06-23 | 公開日 | 2022-12-21 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | 主引用文献 | Crystal Structure Based Mutagenesis of Cattleyene Synthase Leads to the Generation of Rearranged Polycyclic Diterpenes. Angew.Chem.Int.Ed.Engl., 61, 2022
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7DF1
| Crystal structure of human CD98 heavy chain extracellular domain in complex with S1-F4 scFv | 分子名称: | 4F2 cell-surface antigen heavy chain, IGL c2062_light_IGKV4-1_IGKJ5, S1-F4 VH | 著者 | Liu, X, Ding, J, Sui, J, Tian, X. | 登録日 | 2020-11-06 | 公開日 | 2022-12-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.806 Å) | 主引用文献 | An anti-CD98 antibody displaying pH-dependent Fc-mediated tumour-specific activity against multiple cancers in CD98-humanized mice. Nat Biomed Eng, 2022
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5YE9
| The crystal structure of Lp-PLA2 in complex with a novel inhibitor | 分子名称: | N-[4-[(3-cyano-4-naphthalen-2-yloxy-phenyl)sulfamoyl]phenyl]ethanamide, Platelet-activating factor acetylhydrolase, SULFATE ION | 著者 | Liu, Q.F, Xu, Y.C. | 登録日 | 2017-09-15 | 公開日 | 2018-07-25 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.876 Å) | 主引用文献 | Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2. J. Med. Chem., 60, 2017
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5YE7
| The crystal structure of Lp-PLA2 in complex with a novel inhibitor | 分子名称: | N-[4-[(4-naphthalen-2-yloxyphenyl)sulfamoyl]phenyl]ethanamide, Platelet-activating factor acetylhydrolase, SULFATE ION | 著者 | Liu, Q.F, Xu, Y.C. | 登録日 | 2017-09-15 | 公開日 | 2018-07-25 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.312 Å) | 主引用文献 | Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2. J. Med. Chem., 60, 2017
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5YE8
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6DLG
| Crystal structure of a SHIP1 surface entropy reduction mutant | 分子名称: | ISOPROPYL ALCOHOL, Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 | 著者 | Gardill, B.R, Cheung, S.T, Mui, A.L, Van Petegem, F. | 登録日 | 2018-06-01 | 公開日 | 2019-06-05 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.499 Å) | 主引用文献 | Interleukin-10 and Small Molecule SHIP1 Allosteric Regulators Trigger Anti-Inflammatory Effects Through SHIP1/STAT3 Complexes Biorxiv, 2020
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5YEA
| The crystal structure of Lp-PLA2 in complex with a novel inhibitor | 分子名称: | 4-[[4-[4-chloranyl-3-(trifluoromethyl)phenoxy]-3-cyano-phenyl]sulfamoyl]benzoic acid, Platelet-activating factor acetylhydrolase, SULFATE ION | 著者 | Liu, Q.F, Xu, Y.C. | 登録日 | 2017-09-15 | 公開日 | 2018-07-25 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.805 Å) | 主引用文献 | Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2. J. Med. Chem., 60, 2017
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7RGK
| DfrA5 complexed with NADPH and 5-(3-(7-(4-(aminomethyl)phenyl)benzo[d][1,3]dioxol-5-yl)but-1-yn-1-yl)-6-ethylpyrimidine-2,4-diamine (UCP1223) | 分子名称: | 5-[(3R)-3-{7-[4-(aminomethyl)phenyl]-2H-1,3-benzodioxol-5-yl}but-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine, Dihydrofolate reductase type 5, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Lombardo, M.N, Wright, D.L. | 登録日 | 2021-07-15 | 公開日 | 2022-05-25 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens. Commun Biol, 5, 2022
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7RGO
| DfrA5 complexed with NADPH and 4'-chloro-3'-(4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl)-[1,1'-biphenyl]-4-carboxamide (UCP1228) | 分子名称: | 4'-chloro-3'-[(2S)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl][1,1'-biphenyl]-4-carboxamide, Dihydrofolate reductase type 5, GLYCEROL, ... | 著者 | Lombardo, M.N, Wright, D.L. | 登録日 | 2021-07-15 | 公開日 | 2022-05-25 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens. Commun Biol, 5, 2022
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7RGJ
| DfrA1 complexed with NADPH and 5-(3-(7-(4-(aminomethyl)phenyl)benzo[d][1,3]dioxol-5-yl)but-1-yn-1-yl)-6-ethylpyrimidine-2,4-diamine (UCP1223) | 分子名称: | 5-[(3R)-3-{7-[4-(aminomethyl)phenyl]-2H-1,3-benzodioxol-5-yl}but-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine, 5-[(3S)-3-{7-[4-(aminomethyl)phenyl]-2H-1,3-benzodioxol-5-yl}but-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine, CALCIUM ION, ... | 著者 | Lombardo, M.N, Wright, D.L. | 登録日 | 2021-07-15 | 公開日 | 2022-05-25 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.44 Å) | 主引用文献 | Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens. Commun Biol, 5, 2022
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7R6G
| Crystal structure of DfrA5 dihydrofolate reductase in complex with TRIMETHOPRIM and NADPH | 分子名称: | Dihydrofolate reductase type 5, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION, ... | 著者 | Estrada, A, Wright, D, Krucinska, J, Erlandsen, H. | 登録日 | 2021-06-22 | 公開日 | 2022-06-29 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens. Commun Biol, 5, 2022
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7REB
| E. coli dihydrofolate reductase complexed with 5-(3-(7-(4-(aminomethyl)phenyl)benzo[d][1,3]dioxol-5-yl)but-1-yn-1-yl)-6-ethylpyrimidine-2,4-diamine (UCP1223) | 分子名称: | 5-[(3R)-3-{7-[4-(aminomethyl)phenyl]-2H-1,3-benzodioxol-5-yl}but-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine, Dihydrofolate reductase, SULFATE ION | 著者 | Lombardo, M.N, Wright, D.L. | 登録日 | 2021-07-12 | 公開日 | 2022-07-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens. Commun Biol, 5, 2022
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7REG
| DfrA1 complexed with NADPH and 4'-chloro-3'-(4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl)-[1,1'-biphenyl]-4-carboxamide (UCP1228) | 分子名称: | 4'-chloro-3'-[(2S)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl][1,1'-biphenyl]-4-carboxamide, CALCIUM ION, Dihydrofolate reductase type 1, ... | 著者 | Lombardo, M.N, Wright, D.L. | 登録日 | 2021-07-12 | 公開日 | 2022-07-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens. Commun Biol, 5, 2022
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5YYL
| Structure of Major Royal Jelly Protein 1 Oligomer | 分子名称: | (3beta,14beta,17alpha)-ergosta-5,24(28)-dien-3-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Tian, W, Chen, Z. | 登録日 | 2017-12-10 | 公開日 | 2018-08-08 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Architecture of the native major royal jelly protein 1 oligomer. Nat Commun, 9, 2018
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4ALA
| Structure of Dengue virus DIII in complex with Fab 2H12 | 分子名称: | ENVELOPE PROTEIN, FAB 2H12 HEAVY CHAIN, FAB 2H12 LIGHT CHAIN, ... | 著者 | Midgley, C.M, Flanagan, A, Mongkolsapaya, J, Grimes, J.M, Screaton, G.R. | 登録日 | 2012-03-02 | 公開日 | 2012-06-06 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Structural Analysis of a Dengue Cross-Reactive Antibody Complexed with Envelope Domain III Reveals the Molecular Basis of Cross-Reactivity. J.Immunol., 188, 2012
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4AL8
| Structure of Dengue virus DIII in complex with Fab 2H12 | 分子名称: | ENVELOPE PROTEIN, FAB 2H12 HEAVY CHAIN, FAB 2H12 LIGHT CHAIN, ... | 著者 | Midgley, C.M, Flanagan, A, Mongkolsapaya, J, Grimes, J.M, Screaton, G.R. | 登録日 | 2012-03-02 | 公開日 | 2012-06-06 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | Structural Analysis of a Dengue Cross-Reactive Antibody Complexed with Envelope Domain III Reveals the Molecular Basis of Cross-Reactivity. J.Immunol., 188, 2012
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7SEG
| Crystal structure of the complex of CD16A bound by an anti-CD16A Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | 著者 | Kiefer, J.R, Wallweber, H.A, Polson, A.G. | 登録日 | 2021-09-30 | 公開日 | 2021-11-24 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.156 Å) | 主引用文献 | A BCMA/CD16A bispecific innate cell engager for the treatment of multiple myeloma. Leukemia, 36, 2022
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4AM0
| Structure of Dengue virus strain 4 DIII in complex with Fab 2H12 | 分子名称: | ENVELOPE PROTEIN,, FAB 2H12, HEAVY CHAIN, ... | 著者 | Midgley, C.M, Flanagan, A, Mongkolsapaya, J, Grimes, J.M, Screaton, G.R. | 登録日 | 2012-03-06 | 公開日 | 2012-06-06 | 最終更新日 | 2019-12-04 | 実験手法 | X-RAY DIFFRACTION (3.02 Å) | 主引用文献 | Structural Analysis of a Dengue Cross-Reactive Antibody Complexed with Envelope Domain III Reveals the Molecular Basis of Cross-Reactivity. J.Immunol., 188, 2012
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6M07
| Crystal structure of Lp-PLA2 in complex with a novel covalent inhibitor | 分子名称: | (2S)-2-[(E)-3-[2-(diethylamino)ethyl-[[4-[4-(trifluoromethyl)-2-[2,2,2-tris(fluoranyl)ethoxy]phenyl]phenyl]methyl]amino]-1-oxidanyl-3-oxidanylidene-prop-1-enyl]pyrrolidine-1-carboxylic acid, Platelet-activating factor acetylhydrolase | 著者 | Hu, H.C, Xu, Y.C. | 登録日 | 2020-02-20 | 公開日 | 2020-12-30 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | 主引用文献 | Identification of Highly Selective Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitors by a Covalent Fragment-Based Approach. J.Med.Chem., 63, 2020
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6M06
| Crystal structure of Lp-PLA2 in complex with a novel covalent inhibitor | 分子名称: | (2S)-2-[(Z)-1,3-bis(oxidanyl)-3-oxidanylidene-prop-1-enyl]pyrrolidine-1-carboxylic acid, Platelet-activating factor acetylhydrolase | 著者 | Hu, H.C, Xu, Y.C. | 登録日 | 2020-02-20 | 公開日 | 2020-12-30 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Identification of Highly Selective Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitors by a Covalent Fragment-Based Approach. J.Med.Chem., 63, 2020
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