7DF1

Crystal structure of human CD98 heavy chain extracellular domain in complex with S1-F4 scFv

Summary for 7DF1

• Entry DOI: 10.2210/pdb7df1/pdb
• Descriptor: 4F2 cell-surface antigen heavy chain, S1-F4 VH, IGL c2062_light_IGKV4-1_IGKJ5 (3 entities in total)
• Functional Keywords: complex, tumor growth, antibody, antitumor protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 12
• Total formula weight: 298265.29

Authors

Liu, X.,Ding, J.,Sui, J.,Tian, X. (deposition date: 2020-11-06, release date: 2022-12-07, Last modification date: 2023-11-29)

• Primary citation: Tian, X.,Liu, X.,Ding, J.,Wang, F.,Wang, K.,Liu, J.,Wei, Z.,Hao, X.,Li, Y.,Wei, X.,Zhang, H.,Sui, J.; An anti-CD98 antibody displaying pH-dependent Fc-mediated tumour-specific activity against multiple cancers in CD98-humanized mice.; Nat Biomed Eng, 2022; PubMed: 36424464; DOI: 10.1038/s41551-022-00956-5

Experimental method

X-RAY DIFFRACTION (2.806 Å)