7R6G
Crystal structure of DfrA5 dihydrofolate reductase in complex with TRIMETHOPRIM and NADPH
Summary for 7R6G
| Entry DOI | 10.2210/pdb7r6g/pdb |
| Descriptor | Dihydrofolate reductase type 5, TRIMETHOPRIM, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total) |
| Functional Keywords | dihydrofolate reductase, oxidoreductase |
| Biological source | Escherichia coli |
| Total number of polymer chains | 2 |
| Total formula weight | 37261.55 |
| Authors | Estrada, A.,Wright, D.,Krucinska, J.,Erlandsen, H. (deposition date: 2021-06-22, release date: 2022-06-29, Last modification date: 2023-10-18) |
| Primary citation | Krucinska, J.,Lombardo, M.N.,Erlandsen, H.,Estrada, A.,Si, D.,Viswanathan, K.,Wright, D.L. Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens. Commun Biol, 5:459-459, 2022 Cited by PubMed: 35562546DOI: 10.1038/s42003-022-03384-y PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.61 Å) |
Structure validation
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