7RGK
DfrA5 complexed with NADPH and 5-(3-(7-(4-(aminomethyl)phenyl)benzo[d][1,3]dioxol-5-yl)but-1-yn-1-yl)-6-ethylpyrimidine-2,4-diamine (UCP1223)
Summary for 7RGK
Entry DOI | 10.2210/pdb7rgk/pdb |
Descriptor | Dihydrofolate reductase type 5, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION, ... (5 entities in total) |
Functional Keywords | inhibitor, complex, antifolate, dhfr, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Escherichia coli |
Total number of polymer chains | 2 |
Total formula weight | 37796.05 |
Authors | Lombardo, M.N.,Wright, D.L. (deposition date: 2021-07-15, release date: 2022-05-25, Last modification date: 2023-10-18) |
Primary citation | Krucinska, J.,Lombardo, M.N.,Erlandsen, H.,Estrada, A.,Si, D.,Viswanathan, K.,Wright, D.L. Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens. Commun Biol, 5:459-459, 2022 Cited by PubMed: 35562546DOI: 10.1038/s42003-022-03384-y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.19 Å) |
Structure validation
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