7RGK

DfrA5 complexed with NADPH and 5-(3-(7-(4-(aminomethyl)phenyl)benzo[d][1,3]dioxol-5-yl)but-1-yn-1-yl)-6-ethylpyrimidine-2,4-diamine (UCP1223)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Dihydrofolate reductase type 5	polymer	157	17547.0	2	UniProt (P11731) Pfam (PF00186)	Escherichia coli	Dihydrofolate reductase type V
2	C, G (A, B)	NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		743.4	2	Chemie (NAP)
3	D, E, H, I (A, B)	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
4	F, J (A, B)	5-[(3R)-3-{7-[4-(aminomethyl)phenyl]-2H-1,3-benzodioxol-5-yl}but-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine	non-polymer		415.5	2	Chemie (560)
5	K, L (A, B)	water	water		18.0	41	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	35094.0
Non-Polymers*	Number of molecules	8
	Total formula weight	2702.0
All*	Total formula weight	37796.0

*Water molecules are not included.