5YE8
The crystal structure of Lp-PLA2 in complex with a novel inhibitor
Summary for 5YE8
Entry DOI | 10.2210/pdb5ye8/pdb |
Descriptor | Platelet-activating factor acetylhydrolase, N-[3,4-bis(fluoranyl)phenyl]methanesulfonamide (3 entities in total) |
Functional Keywords | hydrolase inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 88226.03 |
Authors | |
Primary citation | Liu, Q.,Huang, F.,Yuan, X.,Wang, K.,Zou, Y.,Shen, J.,Xu, Y. Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2. J. Med. Chem., 60:10231-10244, 2017 Cited by PubMed: 29193967DOI: 10.1021/acs.jmedchem.7b01530 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.851 Å) |
Structure validation
Download full validation report