5YE8
The crystal structure of Lp-PLA2 in complex with a novel inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B, A | Platelet-activating factor acetylhydrolase | polymer | 388 | 43905.8 | 2 | UniProt (Q13093) Pfam (PF03403) In PDB | Homo sapiens (Human) | Lp-PLA2,PAF acetylhydrolase,1-alkyl-2-acetylglycerophosphocholine esterase,2-acetyl-1-alkylglycerophosphocholine esterase,Group-VIIA phospholipase A2,gVIIA-PLA2,LDL-associated phospholipase A2,LDL-PLA(2),PAF 2-acylhydrolase |
2 | B, A | N-[3,4-bis(fluoranyl)phenyl]methanesulfonamide | non-polymer | 207.2 | 2 | Chemie (8U3) | |||
3 | water | water | 18.0 | 293 | Chemie (HOH) |
Sequence modifications
B, A: 47 - 429 (UniProt: Q13093)
PDB | External Database | Details |
---|---|---|
Gly 42 | - | expression tag |
Pro 43 | - | expression tag |
Leu 44 | - | expression tag |
Gly 45 | - | expression tag |
Ser 46 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 87811.6 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 414.4 | |
All* | Total formula weight | 88226.0 |