7RGJ

DfrA1 complexed with NADPH and 5-(3-(7-(4-(aminomethyl)phenyl)benzo[d][1,3]dioxol-5-yl)but-1-yn-1-yl)-6-ethylpyrimidine-2,4-diamine (UCP1223)

Summary for 7RGJ

• Entry DOI: 10.2210/pdb7rgj/pdb
• Descriptor: Dihydrofolate reductase type 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CALCIUM ION, ... (6 entities in total)
• Functional Keywords: inhibitor, complex, antifolate, dhfr, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 37997.47

Authors

Lombardo, M.N.,Wright, D.L. (deposition date: 2021-07-15, release date: 2022-05-25, Last modification date: 2023-10-18)

• Primary citation: Krucinska, J.,Lombardo, M.N.,Erlandsen, H.,Estrada, A.,Si, D.,Viswanathan, K.,Wright, D.L.; Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens.; Commun Biol, 5:459-459, 2022; PubMed: 35562546; DOI: 10.1038/s42003-022-03384-y

Experimental method

X-RAY DIFFRACTION (1.44 Å)