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5H1V
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BU of 5h1v by Molmil
Complex structure of TRIM24 PHD-bromodomain and inhibitor 6
分子名称: 2-Hydrazino-1,3-benzothiazole-6-carbohydrazide, DIMETHYL SULFOXIDE, Transcription intermediary factor 1-alpha, ...
著者Liu, J.
登録日2016-10-11
公開日2017-02-22
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.002 Å)
主引用文献The polar warhead of a TRIM24 bromodomain inhibitor rearranges a water-mediated interaction network
FEBS J., 284, 2017
8WZB
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BU of 8wzb by Molmil
RS head-neck monomer
分子名称: DPY30 domain containing 2, DnaJ homolog subfamily B member 13, Nucleoside diphosphate kinase homolog 5, ...
著者Meng, X, Cong, Y.
登録日2023-11-01
公開日2024-02-07
実験手法ELECTRON MICROSCOPY (3.28 Å)
主引用文献Multi-scale structures of the mammalian radial spoke and divergence of axonemal complexes in ependymal cilia.
Nat Commun, 15, 2024
8X2U
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BU of 8x2u by Molmil
Radial spoke head-neck dimer
分子名称: DPY30 domain containing 2, DnaJ homolog subfamily B member 13, Nucleoside diphosphate kinase homolog 5, ...
著者Meng, X, Cong, Y.
登録日2023-11-10
公開日2024-02-07
実験手法ELECTRON MICROSCOPY (3.57 Å)
主引用文献Multi-scale structures of the mammalian radial spoke and divergence of axonemal complexes in ependymal cilia.
Nat Commun, 15, 2024
4JWF
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BU of 4jwf by Molmil
Crystal structure of spTrm10(74)-SAH complex
分子名称: ACETIC ACID, S-ADENOSYL-L-HOMOCYSTEINE, tRNA (guanine(9)-N1)-methyltransferase
著者Yan, W, Shao, Z.
登録日2013-03-27
公開日2013-10-16
最終更新日2014-02-12
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate.
Nucleic Acids Res., 42, 2014
6L1F
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BU of 6l1f by Molmil
Crystal structure of PHF20L1 Tudor1 in complex with K142me1 DNMT1
分子名称: PHD finger protein 20-like protein 1, the K142me1 DNMT1 peptide
著者Lv, M.Q, Gao, J.
登録日2019-09-29
公開日2020-09-23
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Conformational Selection in Ligand Recognition by the First Tudor Domain of PHF20L1.
J Phys Chem Lett, 11, 2020
5X26
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BU of 5x26 by Molmil
Crystal structure of EGFR 696-1022 L858R in complex with SKLB(3)
分子名称: CHLORIDE ION, Epidermal growth factor receptor, N2-[4-(4-methylpiperazin-1-yl)phenyl]-N8-phenyl-9-propan-2-yl-purine-2,8-diamine
著者Yun, C.H.
登録日2017-01-31
公開日2018-02-07
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.951 Å)
主引用文献Structural insights into drug development strategy targeting EGFR T790M/C797S.
Oncotarget, 9, 2018
5X2K
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BU of 5x2k by Molmil
Crystal structure of EGFR 696-1022 T790M in complex with WZ4003
分子名称: Epidermal growth factor receptor, N-{3-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide
著者Zhu, S.J, Zhao, P, Yun, C.H.
登録日2017-02-01
公開日2018-02-21
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (3.201 Å)
主引用文献Structural insights into drug development strategy targeting EGFR T790M/C797S.
Oncotarget, 9, 2018
5XGM
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BU of 5xgm by Molmil
Crystal structure of EGFR 696-1022 T790M in complex with Go6976
分子名称: 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole, Epidermal growth factor receptor
著者Kong, L.L, Yun, C.H.
登録日2017-04-14
公開日2017-10-11
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.952 Å)
主引用文献Structural pharmacological studies on EGFR T790M/C797S.
Biochem. Biophys. Res. Commun., 488, 2017
5YJ8
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BU of 5yj8 by Molmil
Identification of a small molecule inhibitor for the Tudor domain of TDRD3
分子名称: 5-(aminomethyl)-1,3-dimethyl-benzimidazol-2-one, SULFATE ION, Tudor domain-containing protein 3
著者Liu, J, Ruan, K.
登録日2017-10-09
公開日2018-05-02
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.762 Å)
主引用文献Structural plasticity of the TDRD3 Tudor domain probed by a fragment screening hit.
FEBS J., 285, 2018
5Y5W
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BU of 5y5w by Molmil
Crystal structure of human Spindlin1 in complex with a histone H4K20(me3) peptide
分子名称: Histone peptide H4K20(me3), Spindlin-1
著者Wang, C, Zang, J.
登録日2017-08-10
公開日2017-10-11
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Spindlin-1 recognizes methylations of K20 and R23 of histone H4 tail
FEBS Lett., 592, 2018
5XZU
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BU of 5xzu by Molmil
Crystal structure of GH10 xylanase from Bispora. sp MEY-1 with xylobiose
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-xylanase, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose
著者You, S, Chen, C.C, Tu, T, Guo, R.T, Luo, H.Y, Yao, B.
登録日2017-07-14
公開日2018-05-02
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Insight into the functional roles of Glu175 in the hyperthermostable xylanase XYL10C-Delta N through structural analysis and site-saturation mutagenesis.
Biotechnol Biofuels, 11, 2018
5YJ5
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BU of 5yj5 by Molmil
structure for wildtype Human prion protein (M129)
分子名称: Major prion protein
著者Zheng, Z, Lin, D.
登録日2017-10-08
公開日2018-04-11
最終更新日2019-04-24
実験手法SOLUTION NMR
主引用文献Structural basis for the complete resistance of the human prion protein mutant G127V to prion disease.
Sci Rep, 8, 2018
5YJ4
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BU of 5yj4 by Molmil
structure for the protective mutant G127V of Human prion protein
分子名称: Major prion protein
著者Zheng, Z, Lin, D.
登録日2017-10-07
公開日2018-04-11
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Structural basis for the complete resistance of the human prion protein mutant G127V to prion disease.
Sci Rep, 8, 2018
5X27
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BU of 5x27 by Molmil
Crystal structure of EGFR 696-1022 L858R in complex with SKLB(5)
分子名称: 9-cyclopentyl-N2-[4-(4-methylpiperazin-1-yl)phenyl]-N8-phenyl-purine-2,8-diamine, CHLORIDE ION, Epidermal growth factor receptor
著者Yun, C.H.
登録日2017-01-31
公開日2018-02-07
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.952 Å)
主引用文献Structural insights into drug development strategy targeting EGFR T790M/C797S.
Oncotarget, 9, 2018
5XGN
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BU of 5xgn by Molmil
Crystal structure of EGFR 696-1022 T790M/C797S in complex with Go6976
分子名称: 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole, CHLORIDE ION, Epidermal growth factor receptor
著者Kong, L.L, Yun, C.H.
登録日2017-04-14
公開日2017-10-11
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural pharmacological studies on EGFR T790M/C797S.
Biochem. Biophys. Res. Commun., 488, 2017
5X28
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BU of 5x28 by Molmil
Crystal structure of EGFR 696-1022 L858R in complex with SKLB(6)
分子名称: 9-cyclohexyl-N2-[4-(4-methylpiperazin-1-yl)phenyl]-N8-phenyl-purine-2,8-diamine, CHLORIDE ION, Epidermal growth factor receptor
著者Yun, C.H.
登録日2017-01-31
公開日2018-02-07
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.952 Å)
主引用文献Structural insights into drug development strategy targeting EGFR T790M/C797S.
Oncotarget, 9, 2018
5X2C
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BU of 5x2c by Molmil
Crystal structure of EGFR 696-1022 T790M/V948R in complex with SKLB(5)
分子名称: 1,2-ETHANEDIOL, 9-cyclopentyl-N2-[4-(4-methylpiperazin-1-yl)phenyl]-N8-phenyl-purine-2,8-diamine, CHLORIDE ION, ...
著者Yun, C.H.
登録日2017-01-31
公開日2018-02-21
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structural insights into drug development strategy targeting EGFR T790M/C797S.
Oncotarget, 9, 2018
5X2F
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BU of 5x2f by Molmil
Crystal structure of EGFR 696-1022 T790M/V948R in complex with SKLB(6)
分子名称: 9-cyclohexyl-N2-[4-(4-methylpiperazin-1-yl)phenyl]-N8-phenyl-purine-2,8-diamine, Epidermal growth factor receptor
著者Yun, C.H.
登録日2017-01-31
公開日2018-02-07
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural insights into drug development strategy targeting EGFR T790M/C797S.
Oncotarget, 9, 2018
7WNM
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BU of 7wnm by Molmil
Structure of SARS-CoV-2 Gamma variant receptor-binding domain complexed with high affinity human ACE2 mutant (T27F,R273Q)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike protein S1, ...
著者Ma, R.Y, Han, P.C, Wang, Q.H, Han, P.
登録日2022-01-18
公開日2022-12-21
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献A binding-enhanced but enzymatic activity-eliminated human ACE2 efficiently neutralizes SARS-CoV-2 variants.
Signal Transduct Target Ther, 7, 2022
5X2A
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BU of 5x2a by Molmil
Crystal structure of EGFR 696-1022 T790M/V948R in complex with SKLB(3)
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Epidermal growth factor receptor, ...
著者Yun, C.H.
登録日2017-01-31
公開日2018-02-07
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural insights into drug development strategy targeting EGFR T790M/C797S.
Oncotarget, 9, 2018
2MMF
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BU of 2mmf by Molmil
Solution structure of AGA modified
分子名称: DNA_(5'-D(*CP*TP*AP*AP*(FAG)P*AP*TP*TP*CP*A)-3'), DNA_(5'-D(*TP*GP*AP*AP*TP*CP*TP*TP*AP*G)-3')
著者Li, L, Stone, M.
登録日2014-03-14
公開日2015-02-25
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献DNA Sequence Modulates Geometrical Isomerism of the trans-8,9-Dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl-formamido)-9-hydroxy Aflatoxin B1 Adduct.
Chem.Res.Toxicol., 28, 2015
2MMR
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BU of 2mmr by Molmil
AGC FAPY modified duplex Major isomer
分子名称: DNA_(5'-D(*CP*TP*AP*AP*(FAG)P*CP*TP*TP*CP*A)-3'), DNA_(5'-D(*TP*GP*AP*AP*GP*CP*TP*TP*AP*G)-3')
著者Li, L, Stone, M.
登録日2014-03-17
公開日2015-02-25
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献DNA Sequence Modulates Geometrical Isomerism of the trans-8,9-Dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl-formamido)-9-hydroxy Aflatoxin B1 Adduct.
Chem.Res.Toxicol., 28, 2015
2MMS
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BU of 2mms by Molmil
AG(7-deaza)G FAPY modified duplex
分子名称: DNA_(5'-D(*CP*TP*AP*AP*(FAG)P*(7GU)P*TP*TP*CP*A)-3'), DNA_(5'-D(*TP*GP*AP*AP*CP*CP*TP*TP*AP*G)-3')
著者Li, L, Stone, M.
登録日2014-03-17
公開日2015-02-25
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献DNA Sequence Modulates Geometrical Isomerism of the trans-8,9-Dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl-formamido)-9-hydroxy Aflatoxin B1 Adduct.
Chem.Res.Toxicol., 28, 2015
4JWJ
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BU of 4jwj by Molmil
Crystal structure of scTrm10(84)-SAH complex
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ...
著者Yan, W, Shao, Z.
登録日2013-03-27
公開日2013-10-16
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate.
Nucleic Acids Res., 42, 2014
4JWG
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BU of 4jwg by Molmil
Crystal structure of spTrm10(74)
分子名称: ACETIC ACID, tRNA (guanine(9)-N1)-methyltransferase
著者Yan, W, Shao, Z.
登録日2013-03-27
公開日2013-10-16
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate.
Nucleic Acids Res., 42, 2014

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