7WNM

Structure of SARS-CoV-2 Gamma variant receptor-binding domain complexed with high affinity human ACE2 mutant (T27F,R273Q)

Summary for 7WNM

• Entry DOI: 10.2210/pdb7wnm/pdb
• Descriptor: Angiotensin-converting enzyme 2, Spike protein S1, ZINC ION, ... (5 entities in total)
• Functional Keywords: complex, viral protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 113353.43

Authors

Ma, R.Y.,Han, P.C.,Wang, Q.H.,Han, P. (deposition date: 2022-01-18, release date: 2022-12-21, Last modification date: 2023-11-29)

• Primary citation: Zheng, A.,Wu, L.,Ma, R.,Han, P.,Huang, B.,Qiao, C.,Wang, Q.,Tan, W.,Gao, G.F.,Han, P.; A binding-enhanced but enzymatic activity-eliminated human ACE2 efficiently neutralizes SARS-CoV-2 variants.; Signal Transduct Target Ther, 7:10-10, 2022; PubMed: 35013100; DOI: 10.1038/s41392-021-00821-y

Experimental method

X-RAY DIFFRACTION (2.7 Å)