7WNM
Structure of SARS-CoV-2 Gamma variant receptor-binding domain complexed with high affinity human ACE2 mutant (T27F,R273Q)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B | Angiotensin-converting enzyme 2 | polymer | 740 | 85416.4 | 1 | UniProt (Q9BYF1) Pfam (PF01401) Pfam (PF16959) In PDB | Homo sapiens (human) | Angiotensin-converting enzyme homolog,ACEH,Angiotensin-converting enzyme-related carboxypeptidase,ACE-related carboxypeptidase,Metalloprotease MPROT15 |
2 | A | Spike protein S1 | polymer | 244 | 27650.4 | 1 | UniProt (P0DTC2) Pfam (PF09408) In PDB | Severe acute respiratory syndrome coronavirus 2 | |
3 | B | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
4 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
5 | water | water | 18.0 | 104 | Chemie (HOH) |
Sequence modifications
B: 1 - 740 (UniProt: Q9BYF1)
A: 319 - 541 (UniProt: P0DTC2)
PDB | External Database | Details |
---|---|---|
Phe 27 | Thr 27 | engineered mutation |
Gln 273 | Arg 273 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met 304 | - | expression tag |
Phe 305 | - | expression tag |
Val 306 | - | expression tag |
Phe 307 | - | expression tag |
Leu 308 | - | expression tag |
Val 309 | - | expression tag |
Leu 310 | - | expression tag |
Leu 311 | - | expression tag |
Pro 312 | - | expression tag |
Leu 313 | - | expression tag |
Val 314 | - | expression tag |
Ser 315 | - | expression tag |
Ser 316 | - | expression tag |
Gln 317 | - | expression tag |
Cys 318 | - | expression tag |
Thr 417 | Lys 417 | variant |
Lys 484 | Glu 484 | variant |
Tyr 501 | Asn 501 | engineered mutation |
His 542 | - | expression tag |
His 543 | - | expression tag |
His 544 | - | expression tag |
His 545 | - | expression tag |
His 546 | - | expression tag |
His 547 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 113066.8 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 286.6 | |
All* | Total formula weight | 113353.4 |