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5X26

Crystal structure of EGFR 696-1022 L858R in complex with SKLB(3)

Summary for 5X26
Entry DOI10.2210/pdb5x26/pdb
Related5X27 5X28
DescriptorEpidermal growth factor receptor, N2-[4-(4-methylpiperazin-1-yl)phenyl]-N8-phenyl-9-propan-2-yl-purine-2,8-diamine, CHLORIDE ION, ... (4 entities in total)
Functional Keywordsegfr, l858r, sklb, transferase
Biological sourceHomo sapiens (Human)
Cellular locationCell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains1
Total formula weight37826.18
Authors
Yun, C.H. (deposition date: 2017-01-31, release date: 2018-02-07, Last modification date: 2023-11-22)
Primary citationZhu, S.J.,Zhao, P.,Yang, J.,Ma, R.,Yan, X.E.,Yang, S.Y.,Yang, J.W.,Yun, C.H.
Structural insights into drug development strategy targeting EGFR T790M/C797S.
Oncotarget, 9:13652-13665, 2018
Cited by
PubMed: 29568384
DOI: 10.18632/oncotarget.24113
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.951 Å)
Structure validation

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