5XGM
Crystal structure of EGFR 696-1022 T790M in complex with Go6976
Summary for 5XGM
Entry DOI | 10.2210/pdb5xgm/pdb |
Related | 5XGN |
Descriptor | Epidermal growth factor receptor, 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole (3 entities in total) |
Functional Keywords | egfr t790m, go6976, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
Total number of polymer chains | 1 |
Total formula weight | 38029.02 |
Authors | Kong, L.L.,Yun, C.H. (deposition date: 2017-04-14, release date: 2017-10-11, Last modification date: 2023-11-22) |
Primary citation | Kong, L.L.,Ma, R.,Yao, M.Y.,Yan, X.E.,Zhu, S.J.,Zhao, P.,Yun, C.H. Structural pharmacological studies on EGFR T790M/C797S. Biochem. Biophys. Res. Commun., 488:266-272, 2017 Cited by PubMed: 28456628DOI: 10.1016/j.bbrc.2017.04.138 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.952 Å) |
Structure validation
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