5X2F

Crystal structure of EGFR 696-1022 T790M/V948R in complex with SKLB(6)

Summary for 5X2F

Entry DOI	10.2210/pdb5x2f/pdb
Related	5X26 5X27 5X28 5X2A 5X2C 5X2K
Descriptor	Epidermal growth factor receptor, 9-cyclohexyl-N2-[4-(4-methylpiperazin-1-yl)phenyl]-N8-phenyl-purine-2,8-diamine (3 entities in total)
Functional Keywords	egfr, t790m, v948r, sklb, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains	4
Total formula weight	152828.88
Authors	Yun, C.H. (deposition date: 2017-01-31, release date: 2018-02-07, Last modification date: 2024-03-27)
Primary citation	Zhu, S.J.,Zhao, P.,Yang, J.,Ma, R.,Yan, X.E.,Yang, S.Y.,Yang, J.W.,Yun, C.H. Structural insights into drug development strategy targeting EGFR T790M/C797S. Oncotarget, 9:13652-13665, 2018 Cited by PubMed: 29568384 DOI: 10.18632/oncotarget.24113 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation