5X2F
Crystal structure of EGFR 696-1022 T790M/V948R in complex with SKLB(6)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Epidermal growth factor receptor | polymer | 331 | 37724.6 | 4 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | E, F, G, H (A, B, C, D) | 9-cyclohexyl-N2-[4-(4-methylpiperazin-1-yl)phenyl]-N8-phenyl-purine-2,8-diamine | non-polymer | 482.6 | 4 | Chemie (7XU) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 380 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 696 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 692 | - | expression tag |
| Ser 693 | - | expression tag |
| Thr 694 | - | expression tag |
| Ser 695 | - | expression tag |
| Met 790 | Thr 790 | engineered mutation |
| Arg 948 | Val 948 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 150898.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1930.5 | |
| All* | Total formula weight | 152828.9 |
