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1E2Q
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BU of 1e2q by Molmil
Human thymidylate kinase complexed with TP5A and a magnesium-ion
分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, THYMIDINE-5'-PHOSPHATE, ...
著者Ostermann, N, Schlichting, I, Brundiers, R, Konrad, M, Reinstein, J, Veit, T, Goody, R.S, Lavie, A.
登録日2000-05-23
公開日2001-05-17
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Insights Into the Phosphoryltransfer Mechanism of Human Thymidylate Kinase Gained from Crystal Structures of Enzyme Complexes Along the Reaction Coordinate
Structure, 8, 2000
1E2E
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Human thymidylate kinase complexed with thymidine monophosphate, adenosine diphosphate,a magnesium-ion and ALf3
分子名称: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ...
著者Ostermann, N, Schlichting, I, Brundiers, R, Konrad, M, Reinstein, J, Veit, T, Goody, R.S, Lavie, A.
登録日2000-05-22
公開日2001-05-17
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Insights Into the Phosphoryltransfer Mechanism of Human Thymidylate Kinase Gained from Crystal Structures of Enzyme Complexes Along the Reaction Coordinate
Structure, 8, 2000
1E2G
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BU of 1e2g by Molmil
Human thymidylate kinase complexed with ADP, TDP and a magnesium-ion
分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, THYMIDINE-5'-DIPHOSPHATE, ...
著者Ostermann, N, Schlichting, I, Brundiers, R, Konrad, M, Reinstein, J, Veit, T, Goody, R.S, Lavie, A.
登録日2000-05-22
公開日2001-05-17
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Insights Into the Phosphoryltransfer Mechanism of Human Thymidylate Kinase Gained from Crystal Structures of Enzyme Complexes Along the Reaction Coordinate
Structure, 8, 2000
1E2D
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BU of 1e2d by Molmil
Human thymidylate kinase complexed with thymidine monophosphate, adenosine diphosphate and a magnesium-ion
分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, THYMIDINE-5'-PHOSPHATE, ...
著者Ostermann, N, Schlichting, I, Brundiers, R, Konrad, M, Reinstein, J, Veit, T, Goody, R.S, Lavie, A.
登録日2000-05-22
公開日2001-05-17
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Insights Into the Phosphoryltransfer Mechanism of Human Thymidylate Kinase Gained from Crystal Structures of Enzyme Complexes Along the Reaction Coordinate
Structure, 8, 2000
1E2F
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BU of 1e2f by Molmil
Human thymidylate kinase complexed with thymidine monophosphate, adenosine diphosphate and a magnesium-ion
分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Ostermann, N, Schlichting, I, Brundiers, R, Konrad, M, Reinstein, J, Veit, T, Goody, R.S, Lavie, A.
登録日2000-05-22
公開日2001-05-17
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Insights Into the Phosphoryltransfer Mechanism of Human Thymidylate Kinase Gained from Crystal Structures of Enzyme Complexes Along the Reaction Coordinate
Structure, 8, 2000
1P62
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BU of 1p62 by Molmil
Structure of human dCK complexed with gemcitabine and ADP-MG
分子名称: ADENOSINE-5'-DIPHOSPHATE, Deoxycytidine kinase, GEMCITABINE, ...
著者Sabini, E, Ort, S, Monnerjahn, C, Konrad, M, Lavie, A.
登録日2003-04-28
公開日2003-07-01
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of human dCK suggests strategies to improve anticancer and antiviral therapy
Nat.Struct.Biol., 10, 2003
1P6X
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BU of 1p6x by Molmil
Crystal structure of EHV4-TK complexed with Thy and SO4
分子名称: SULFATE ION, THYMIDINE, Thymidine kinase
著者Gardberg, A, Shuvalova, L, Monnerjahn, C, Konrad, M, Lavie, A.
登録日2003-04-30
公開日2003-11-04
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.
Structure, 11, 2003
1P61
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Structure of human dCK complexed with 2'-Deoxycytidine and ADP, P 43 21 2 space group
分子名称: 2'-DEOXYCYTIDINE, ADENOSINE-5'-DIPHOSPHATE, Deoxycytidine kinase
著者Sabini, E, Ort, S, Monnerjahn, C, Konrad, M, Lavie, A.
登録日2003-04-28
公開日2003-07-01
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Structure of human dCK suggests strategies to improve anticancer and antiviral therapy
Nat.Struct.Biol., 10, 2003
1P7C
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BU of 1p7c by Molmil
Crystal Structure of HSV1-TK complexed with TP5A
分子名称: P1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE, SULFATE ION, THYMIDINE, ...
著者Gardberg, A, Shuvalova, L, Monnerjahn, C, Konrad, M, Lavie, A.
登録日2003-05-01
公開日2003-11-04
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.
Structure, 11, 2003
1P75
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BU of 1p75 by Molmil
Crystal structure of EHV4-TK complexed with TP5A
分子名称: P1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE, SULFATE ION, Thymidine kinase
著者Gardberg, A, Shuvalova, L, Monnerjahn, C, Konrad, M, Lavie, A.
登録日2003-04-30
公開日2003-11-04
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (3.02 Å)
主引用文献Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.
Structure, 11, 2003
1P72
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BU of 1p72 by Molmil
Crystal structure of EHV4-TK complexed with Thy and ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, SULFATE ION, THYMIDINE, ...
著者Gardberg, A, Shuvalova, L, Monnerjahn, C, Konrad, M, Lavie, A.
登録日2003-04-30
公開日2003-11-04
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.
Structure, 11, 2003
1P73
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BU of 1p73 by Molmil
Crystal structure of EHV4-TK complexed with TP4A
分子名称: P1-(5'-ADENOSYL)P4-(5'-(2'-DEOXY-THYMIDYL))TETRAPHOSPHATE, SULFATE ION, Thymidine kinase
著者Gardberg, A, Shuvalova, L, Monnerjahn, C, Konrad, M, Lavie, A.
登録日2003-04-30
公開日2003-11-04
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.
Structure, 11, 2003
1P5Z
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BU of 1p5z by Molmil
Structure of human dCK complexed with cytarabine and ADP-MG
分子名称: ADENOSINE-5'-DIPHOSPHATE, CYTARABINE, Deoxycytidine kinase, ...
著者Sabini, E, Ort, S, Monnerjahn, C, Konrad, M, Lavie, A.
登録日2003-04-28
公開日2003-07-01
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure of human dCK suggests strategies to improve anticancer and antiviral therapy
Nat.Struct.Biol., 10, 2003
1P60
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BU of 1p60 by Molmil
Structure of human dCK complexed with 2'-Deoxycytidine and ADP, Space group C 2 2 21
分子名称: 2'-DEOXYCYTIDINE, ADENOSINE-5'-DIPHOSPHATE, Deoxycytidine kinase
著者Sabini, E, Ort, S, Monnerjahn, C, Konrad, M, Lavie, A.
登録日2003-04-28
公開日2003-07-01
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Structure of human dCK suggests strategies to improve anticancer and antiviral therapy
Nat.Struct.Biol., 10, 2003
2ORW
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BU of 2orw by Molmil
Thermotoga maritima thymidine kinase 1 like enzyme in complex with TP4A
分子名称: MAGNESIUM ION, P1-(5'-ADENOSYL)P4-(5'-(2'-DEOXY-THYMIDYL))TETRAPHOSPHATE, Thymidine kinase, ...
著者Segura-Pena, D, Lutz, S, Monnerjahn, C, Konrad, M, Lavie, A.
登録日2007-02-04
公開日2007-03-27
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Binding of ATP to TK1-like Enzymes Is Associated with a Conformational Change in the Quaternary Structure.
J.Mol.Biol., 369, 2007
2NO7
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BU of 2no7 by Molmil
C4S dCK variant of dCK in complex with L-dC+ADP
分子名称: 4-AMINO-1-(2-DEOXY-BETA-L-ERYTHRO-PENTOFURANOSYL)PYRIMIDIN-2(1H)-ONE, ADENOSINE-5'-DIPHOSPHATE, deoxycytidine kinase
著者Sabini, E, Hazra, S, Konrad, M, Burley, S.K, Lavie, A.
登録日2006-10-25
公開日2007-07-03
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Nonenantioselectivity Property of Human Deoxycytidine Kinase Explained by Structures of the Enzyme in Complex with l- and d-Nucleosides.
J.Med.Chem., 50, 2007
2NO0
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BU of 2no0 by Molmil
C4S dCK variant of dCK in complex with gemcitabine+ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, Deoxycytidine kinase, GEMCITABINE
著者Sabini, E, Hazra, S, Konrad, M, Burley, S.K, Lavie, A.
登録日2006-10-24
公開日2007-07-03
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Nonenantioselectivity Property of Human Deoxycytidine Kinase Explained by Structures of the Enzyme in Complex with l- and d-Nucleosides.
J.Med.Chem., 50, 2007
2NO1
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BU of 2no1 by Molmil
C4S dCK variant of dCK in complex with D-dC+ADP
分子名称: 2'-DEOXYCYTIDINE, ADENOSINE-5'-DIPHOSPHATE, deoxycytidine kinase
著者Sabini, E, Hazra, S, Konrad, M, Burley, S.K, Lavie, A.
登録日2006-10-24
公開日2007-07-03
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Nonenantioselectivity Property of Human Deoxycytidine Kinase Explained by Structures of the Enzyme in Complex with l- and d-Nucleosides.
J.Med.Chem., 50, 2007
2ORV
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BU of 2orv by Molmil
human Thymidine Kinase 1 in complex with TP4A
分子名称: P1-(5'-ADENOSYL)P4-(5'-(2'-DEOXY-THYMIDYL))TETRAPHOSPHATE, Thymidine kinase, ZINC ION
著者Segura-Pena, D, Lutz, S, Monnerjahn, C, Konrad, M, Lavie, A.
登録日2007-02-04
公開日2007-03-27
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Binding of ATP to TK1-like Enzymes Is Associated with a Conformational Change in the Quaternary Structure.
J.Mol.Biol., 369, 2007
2NO6
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BU of 2no6 by Molmil
C4S dCK variant of dCK in complex with FTC+ADP
分子名称: 4-AMINO-5-FLUORO-1-[(2R,5S)-2-(HYDROXYMETHYL)-1,3-OXATHIOLAN-5-YL]PYRIMIDIN-2(1H)-ONE, ADENOSINE-5'-DIPHOSPHATE, deoxycytidine kinase
著者Sabini, E, Hazra, S, Konrad, M, Burley, S.K, Lavie, A.
登録日2006-10-25
公開日2007-07-03
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Nonenantioselectivity Property of Human Deoxycytidine Kinase Explained by Structures of the Enzyme in Complex with l- and d-Nucleosides.
J.Med.Chem., 50, 2007
2TMK
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BU of 2tmk by Molmil
YEAST THYMIDYLATE KINASE COMPLEXED WITH 3'-AZIDO-3'-DEOXYTHYMIDINE MONOPHOSPHATE (AZT-MP)
分子名称: 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, SULFATE ION, THYMIDYLATE KINASE
著者Lavie, A, Schlichting, I.
登録日1997-06-12
公開日1998-06-17
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation.
Nat.Struct.Biol., 4, 1997
5TMP
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BU of 5tmp by Molmil
COMPLEX OF E. COLI THYMIDYLATE KINASE WITH THE BISUBSTRATE INHIBITOR AZTP5A
分子名称: P1-(5'-ADENOSYL)P5-(5'-(3'AZIDO-3'-DEOXYTHYMIDYL))PENTAPHOSPHATE, PROTEIN (THYMIDYLATE KINASE)
著者Lavie, A, Ostermann, N, Schlichting, I.
登録日1998-09-01
公開日1998-11-25
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Structural basis for efficient phosphorylation of 3'-azidothymidine monophosphate by Escherichia coli thymidylate kinase.
Proc.Natl.Acad.Sci.USA, 95, 1998
1TMK
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BU of 1tmk by Molmil
YEAST THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE (DTMP)
分子名称: SULFATE ION, THYMIDINE-5'-PHOSPHATE, THYMIDYLATE KINASE
著者Lavie, A, Schlichting, I.
登録日1997-06-12
公開日1998-06-17
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation.
Nat.Struct.Biol., 4, 1997
3MJR
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BU of 3mjr by Molmil
Human dCK complex with Acyclic Nucleoside
分子名称: 9-HYROXYETHOXYMETHYLGUANINE, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE
著者Hazra, S, Lavie, A.
登録日2010-04-13
公開日2010-07-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The Sugar Ring of the Nucleoside Is Required for Productive Substrate Positioning in the Active Site of Human Deoxycytidine Kinase (dCK): Implications for the Development of dCK-Activated Acyclic Guanine Analogues.
J.Med.Chem., 53, 2010
3HP1
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BU of 3hp1 by Molmil
Crystal structure of human dCK R104M/D133A in complex with L-dT and ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, Deoxycytidine kinase, L-deoxythymidine
著者Hazra, S, Lavie, A.
登録日2009-06-03
公開日2009-06-16
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Extending Thymidine Kinase Activity to the Catalytic Repertoire of Human Deoxycytidine Kinase.
Biochemistry, 48, 2009

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