2NO0

C4S dCK variant of dCK in complex with gemcitabine+ADP

Summary for 2NO0

Entry DOI	10.2210/pdb2no0/pdb
Related	1P5Z 1P60 1P61 1P62 2A2Z 2A30 2NO1
Descriptor	Deoxycytidine kinase, ADENOSINE-5'-DIPHOSPHATE, GEMCITABINE, ... (4 entities in total)
Functional Keywords	dck, gemcitabine, human deoxycytidine kinase, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	66699.97
Authors	Sabini, E.,Hazra, S.,Konrad, M.,Burley, S.K.,Lavie, A. (deposition date: 2006-10-24, release date: 2007-07-03, Last modification date: 2023-08-30)
Primary citation	Sabini, E.,Hazra, S.,Konrad, M.,Lavie, A. Nonenantioselectivity Property of Human Deoxycytidine Kinase Explained by Structures of the Enzyme in Complex with l- and d-Nucleosides. J.Med.Chem., 50:3004-3014, 2007 Cited by PubMed: 17530837 DOI: 10.1021/jm0700215 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation