3MJR

Human dCK complex with Acyclic Nucleoside

Summary for 3MJR

• Entry DOI: 10.2210/pdb3mjr/pdb
• Descriptor: Deoxycytidine kinase, 9-HYROXYETHOXYMETHYLGUANINE, URIDINE-5'-DIPHOSPHATE, ... (4 entities in total)
• Functional Keywords: acv, gcv, dck, kinase, udp, p-loop, kinase activity, nucleoside kinase, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : P27707
• Total number of polymer chains: 4
• Total formula weight: 132582.30

Authors

Hazra, S.,Lavie, A. (deposition date: 2010-04-13, release date: 2010-07-28, Last modification date: 2023-09-06)

• Primary citation: Hazra, S.,Konrad, M.,Lavie, A.; The Sugar Ring of the Nucleoside Is Required for Productive Substrate Positioning in the Active Site of Human Deoxycytidine Kinase (dCK): Implications for the Development of dCK-Activated Acyclic Guanine Analogues.; J.Med.Chem., 53:5792-5800, 2010; PubMed: 20684612; DOI: 10.1021/jm1005379

Experimental method

X-RAY DIFFRACTION (2.1 Å)