1P7C

Crystal Structure of HSV1-TK complexed with TP5A

Summary for 1P7C

• Entry DOI: 10.2210/pdb1p7c/pdb
• Related: 1P6X 1P72 1P73 1P75
• Descriptor: Thymidine kinase, P1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE, SULFATE ION, ... (5 entities in total)
• Functional Keywords: p-loop, lid, bisubstrate inhibitor, transferase
• Biological source: Herpes simplex virus (type 1 / strain 17)
• Total number of polymer chains: 2
• Total formula weight: 75640.86

Authors

Gardberg, A.,Shuvalova, L.,Monnerjahn, C.,Konrad, M.,Lavie, A. (deposition date: 2003-05-01, release date: 2003-11-04, Last modification date: 2023-08-16)

• Primary citation: Gardberg, A.,Shuvalova, L.,Monnerjahn, C.,Konrad, M.,Lavie, A.; Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.; Structure, 11:1265-1277, 2003; PubMed: 14527394; DOI: 10.1016/j.str.2003.09.003

Experimental method

X-RAY DIFFRACTION (2.1 Å)