1E2E

Human thymidylate kinase complexed with thymidine monophosphate, adenosine diphosphate,a magnesium-ion and ALf3

Summary for 1E2E

Entry DOI	10.2210/pdb1e2e/pdb
Related	1E2D 1E2F 1E2G 1E2Q 1E98 1E99 1E9A 1E9B 1E9C 1E9D 1E9E 1E9F 1TMK 2TMK 3TMK
Descriptor	THYMIDYLATE KINASE, THYMIDINE-5'-PHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ... (6 entities in total)
Functional Keywords	thymidylate kinase, p-loop
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	24934.53
Authors	Ostermann, N.,Schlichting, I.,Brundiers, R.,Konrad, M.,Reinstein, J.,Veit, T.,Goody, R.S.,Lavie, A. (deposition date: 2000-05-22, release date: 2001-05-17, Last modification date: 2024-05-08)
Primary citation	Ostermann, N.,Schlichting, I.,Brundiers, R.,Konrad, M.,Reinstein, J.,Veit, T.,Goody, R.S.,Lavie, A. Insights Into the Phosphoryltransfer Mechanism of Human Thymidylate Kinase Gained from Crystal Structures of Enzyme Complexes Along the Reaction Coordinate Structure, 8:629-, 2000 Cited by PubMed Abstract: Thymidylate kinase (TMPK) is a nucleoside monophosphate kinase that catalyzes the reversible phosphoryltransfer between ATP and TMP to yield ADP and TDP. In addition to its vital role in supplying precursors for DNA synthesis, human TMPK has an important medical role participating in the activation of a number of anti-HIV prodrugs. PubMed: 10873853 DOI: 10.1016/S0969-2126(00)00149-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation