1E2D

Human thymidylate kinase complexed with thymidine monophosphate, adenosine diphosphate and a magnesium-ion

Summary for 1E2D

Entry DOI	10.2210/pdb1e2d/pdb
Related	1E2E 1E2F 1E2G 1E2Q 1E98 1E99 1E9A 1E9B 1E9C 1E9D 1E9E 1E9F 1TMK 2TMK 3TMK
Descriptor	THYMIDYLATE KINASE, THYMIDINE-5'-PHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
Functional Keywords	phosphotransferase, thymidylate kinase, p-loop
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	24874.86
Authors	Ostermann, N.,Schlichting, I.,Brundiers, R.,Konrad, M.,Reinstein, J.,Veit, T.,Goody, R.S.,Lavie, A. (deposition date: 2000-05-22, release date: 2001-05-17, Last modification date: 2023-12-06)
Primary citation	Ostermann, N.,Schlichting, I.,Brundiers, R.,Konrad, M.,Reinstein, J.,Veit, T.,Goody, R.S.,Lavie, A. Insights Into the Phosphoryltransfer Mechanism of Human Thymidylate Kinase Gained from Crystal Structures of Enzyme Complexes Along the Reaction Coordinate Structure, 8:629-, 2000 Cited by PubMed: 10873853 DOI: 10.1016/S0969-2126(00)00149-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation