1E2D
Human thymidylate kinase complexed with thymidine monophosphate, adenosine diphosphate and a magnesium-ion
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | THYMIDYLATE KINASE | polymer | 215 | 24052.5 | 1 | UniProt (P23919) Pfam (PF02223) | HOMO SAPIENS (HUMAN) | TMPK |
| 2 | B (A) | THYMIDINE-5'-PHOSPHATE | non-polymer | 322.2 | 1 | Chemie (TMP) PubChem (18531120) PubChem (20711568) PubChem (1139) PubChem (23657880) PubChem (24802545) PubChem (44361457) PubChem (25113134) PubChem (51397487) PubChem (444919) PubChem (9700) PubChem (5274091) PubChem (5748250) PubChem (10147784) PubChem (129069890) PubChem (133126478) PubChem (164603144) | |||
| 3 | C (A) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 4 | D, E, F (A) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) PubChem (888) | |||
| 5 | G (A) | water | water | 18.0 | 291 | Chemie (HOH) |
Sequence modifications
A: -2 - 0 (PDB: 1E2D)
A: 1 - 212 (UniProt: P23919)
A: 1 - 212 (UniProt: P23919)
| PDB | External Database | Details |
|---|---|---|
| Ala 200 | Arg 200 | engineered mutation |
| Ser 183 | Arg 183 | conflict |
| Ile 184 | Leu 184 | conflict |
| Asp 190 | Glu 190 | conflict |
| Ile 191 | Leu 191 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 24052.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 822.3 | |
| All* | Total formula weight | 24874.9 |
