2NO6

C4S dCK variant of dCK in complex with FTC+ADP

Summary for 2NO6

• Entry DOI: 10.2210/pdb2no6/pdb
• Related: 1NO7 1P5Z 1P60 1P61 1P62 2A2Z 2A30 2NO0 2NO1 2NO9 2NOA
• Descriptor: deoxycytidine kinase, ADENOSINE-5'-DIPHOSPHATE, 4-AMINO-5-FLUORO-1-[(2R,5S)-2-(HYDROXYMETHYL)-1,3-OXATHIOLAN-5-YL]PYRIMIDIN-2(1H)-ONE, ... (4 entities in total)
• Functional Keywords: dck, emtricitabine, human deoxycytidine kinase, ftc, enantiomer, antiviral, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 66668.07

Authors

Sabini, E.,Hazra, S.,Konrad, M.,Burley, S.K.,Lavie, A. (deposition date: 2006-10-25, release date: 2007-07-03, Last modification date: 2023-08-30)

• Primary citation: Sabini, E.,Hazra, S.,Konrad, M.,Lavie, A.; Nonenantioselectivity Property of Human Deoxycytidine Kinase Explained by Structures of the Enzyme in Complex with l- and d-Nucleosides.; J.Med.Chem., 50:3004-3014, 2007; PubMed: 17530837; DOI: 10.1021/jm0700215

Experimental method

X-RAY DIFFRACTION (1.9 Å)