2NO9

The structure of deoxycytidine kinase complexed with troxacitabine and ADP.

Summary for 2NO9

Entry DOI	10.2210/pdb2no9/pdb
Related	1NO6 1P5Z 1P60 1P61 1P62 2A2Z 2A30 2NO0 2NO1 2NO7 2NOA
Descriptor	deoxycytidine kinase, ADENOSINE-5'-DIPHOSPHATE, 4-AMINO-1-[(2S,4S)-2-(HYDROXYMETHYL)-1,3-DIOXOLAN-4-YL]PYRIMIDIN-2(1H)-ONE, ... (4 entities in total)
Functional Keywords	dck, troxacitabine, human deoxycytidine kinase, l-dc, enantiomer, anticancer, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	66599.96
Authors	Sabini, E.,Lavie, A. (deposition date: 2006-10-25, release date: 2007-02-13, Last modification date: 2023-08-30)
Primary citation	Sabini, E.,Hazra, S.,Konrad, M.,Burley, S.K.,Lavie, A. Structural basis for activation of the therapeutic L-nucleoside analogs 3TC and troxacitabine by human deoxycytidine kinase. Nucleic Acids Res., 35:186-192, 2007 Cited by PubMed: 17158155 DOI: 10.1093/nar/gkl1038 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation