2NOA
The structure of deoxycytidine kinase complexed with lamivudine and ADP.
Summary for 2NOA
Entry DOI | 10.2210/pdb2noa/pdb |
Related | 1NO6 1P5Z 1P60 1P61 1P62 2A2Z 2A30 2NO0 2NO1 2NO7 2NO9 |
Descriptor | deoxycytidine kinase, ADENOSINE-5'-DIPHOSPHATE, 4-AMINO-1-[(2R,5S)-2-(HYDROXYMETHYL)-1,3-OXATHIOLAN-5-YL]PYRIMIDIN-2(1H)-ONE, ... (4 entities in total) |
Functional Keywords | dck, 3tc, human deoxycytidine kinase, l-dc, enantiomer, antiviral, lamivudine, epivir, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 66632.09 |
Authors | Sabini, E.,Lavie, A. (deposition date: 2006-10-25, release date: 2007-02-13, Last modification date: 2023-08-30) |
Primary citation | Sabini, E.,Hazra, S.,Konrad, M.,Burley, S.K.,Lavie, A. Structural basis for activation of the therapeutic L-nucleoside analogs 3TC and troxacitabine by human deoxycytidine kinase. Nucleic Acids Res., 35:186-192, 2007 Cited by PubMed: 17158155DOI: 10.1093/nar/gkl1038 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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