4MNY
| Crystal structure of urokinase-type plasminogen activator (uPA) complexed with bicyclic peptide UK903 | 分子名称: | ACETATE ION, GLYCEROL, N,N',N''-benzene-1,3,5-triyltris(2-bromoacetamide), ... | 著者 | Chen, S, Pojer, F, Heinis, C. | 登録日 | 2013-09-11 | 公開日 | 2014-02-05 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Peptide ligands stabilized by small molecules. Angew.Chem.Int.Ed.Engl., 53, 2014
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4LQ8
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4GLY
| Human urokinase-type plasminogen activator uPA in complex with the two-disulfide bridge peptide UK504 | 分子名称: | BICYCLIC PEPTIDE INHIBITOR UK504, CHLORIDE ION, GLYCEROL, ... | 著者 | Buth, S.A, Leiman, P.G, Chen, S, Heinis, C. | 登録日 | 2012-08-15 | 公開日 | 2013-05-15 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.518 Å) | 主引用文献 | Bicyclic Peptide Ligands Pulled out of Cysteine-Rich Peptide Libraries. J.Am.Chem.Soc., 135, 2013
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6TWC
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6TWB
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4MNX
| Crystal structure of urokinase-type plasminogen activator (uPA) complexed with bicyclic peptide UK811 | 分子名称: | 1,1',1''-(1,3,5-triazinane-1,3,5-triyl)tripropan-1-one, GLYCEROL, SULFATE ION, ... | 著者 | Chen, S, Pojer, F, Heinis, C. | 登録日 | 2013-09-11 | 公開日 | 2014-02-05 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Peptide ligands stabilized by small molecules. Angew.Chem.Int.Ed.Engl., 53, 2014
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2JK4
| Structure of the human voltage-dependent anion channel | 分子名称: | VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL PROTEIN 1 | 著者 | Bayrhuber, M, Meins, T, Habeck, M, Becker, S, Giller, K, Villinger, S, Vonrhein, C, Griesinger, C, Zweckstetter, M, Zeth, K. | 登録日 | 2008-08-15 | 公開日 | 2008-10-14 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (4.1 Å) | 主引用文献 | Structure of the Human Voltage-Dependent Anion Channel. Proc.Natl.Acad.Sci.USA, 105, 2008
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4OS7
| Crystal structure of urokinase-type plasminogen activator (uPA) complexed with bicyclic peptide UK607 (bicyclic) | 分子名称: | ACETATE ION, GLYCEROL, SULFATE ION, ... | 著者 | Chen, S, Pojer, F, Heinis, C. | 登録日 | 2014-02-12 | 公開日 | 2014-09-24 | 最終更新日 | 2021-06-02 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides. Nat Chem, 6, 2014
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4OS2
| Crystal structure of urokinase-type plasminogen activator (uPA) complexed with bicyclic peptide UK602 (bicyclic 1) | 分子名称: | ACETATE ION, SULFATE ION, Urokinase-type plasminogen activator, ... | 著者 | Chen, S, Pojer, F, Heinis, C. | 登録日 | 2014-02-12 | 公開日 | 2014-09-24 | 最終更新日 | 2021-06-02 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides. Nat Chem, 6, 2014
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4JK5
| Human urokinase-type Plasminogen Activator (uPA) in complex with a bicyclic peptide inhibitor (UK18-D-Ser) | 分子名称: | 1,3,5-tris(bromomethyl)benzene, CHLORIDE ION, HEXAETHYLENE GLYCOL, ... | 著者 | Buth, S.A, Leiman, P.G, Chen, S, Heinis, C. | 登録日 | 2013-03-09 | 公開日 | 2013-07-17 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Improving binding affinity and stability of Peptide ligands by substituting glycines with d-amino acids. Chembiochem, 14, 2013
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4JK6
| Human urokinase-type Plasminogen Activator (uPA) in complex with a bicyclic peptide inhibitor (UK18-D-Aba) | 分子名称: | 1,3,5-tris(bromomethyl)benzene, CHLORIDE ION, HEXAETHYLENE GLYCOL, ... | 著者 | Buth, S.A, Leiman, P.G, Chen, S, Heinis, C. | 登録日 | 2013-03-09 | 公開日 | 2013-07-17 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Improving binding affinity and stability of Peptide ligands by substituting glycines with d-amino acids. Chembiochem, 14, 2013
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2YLF
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3CJW
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3FI0
| Crystal Structure Analysis of B. stearothermophilus Tryptophanyl-tRNA Synthetase Complexed with Tryptophan, AMP, and Inorganic Phosphate | 分子名称: | ADENOSINE MONOPHOSPHATE, PHOSPHATE ION, TRYPTOPHAN, ... | 著者 | Laowanapiban, P, Kapustina, M, Vonrhein, C, Delarue, M, Koehl, P, Carter Jr, C.W. | 登録日 | 2008-12-10 | 公開日 | 2009-02-03 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Independent saturation of three TrpRS subsites generates a partially assembled state similar to those observed in molecular simulations. Proc.Natl.Acad.Sci.Usa, 106, 2009
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5D98
| Influenza C Virus RNA-dependent RNA Polymerase - Space group P43212 | 分子名称: | MAGNESIUM ION, Polymerase acidic protein, Polymerase basic protein 2, ... | 著者 | Hengrung, N, El Omari, K, Serna Martin, I, Vreede, F.T, Cusack, S, Rambo, R.P, Vonrhein, C, Bricogne, G, Stuart, D.I, Grimes, J.M, Fodor, E. | 登録日 | 2015-08-18 | 公開日 | 2015-10-21 | 最終更新日 | 2017-09-13 | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | 主引用文献 | Crystal structure of the RNA-dependent RNA polymerase from influenza C virus. Nature, 527, 2015
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5D9A
| Influenza C Virus RNA-dependent RNA Polymerase - Space group P212121 | 分子名称: | Polymerase acidic protein, Polymerase basic protein 2, RNA-directed RNA polymerase catalytic subunit | 著者 | Hengrung, N, El Omari, K, Serna Martin, I, Vreede, F.T, Cusack, S, Rambo, R.P, Vonrhein, C, Bricogne, G, Stuart, D.I, Grimes, J.M, Fodor, E. | 登録日 | 2015-08-18 | 公開日 | 2015-10-21 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (4.3 Å) | 主引用文献 | Crystal structure of the RNA-dependent RNA polymerase from influenza C virus. Nature, 527, 2015
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3FHJ
| Independent saturation of three TrpRS subsites generates a partially-assembled state similar to those observed in molecular simulations | 分子名称: | ADENOSINE MONOPHOSPHATE, PHOSPHATE ION, TRYPTOPHAN, ... | 著者 | Laowanapiban, P, Kapustina, M, Vonrhein, C, Delarue, M, Koehl, P, Carter Jr, C.W. | 登録日 | 2008-12-09 | 公開日 | 2009-02-03 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Independent saturation of three TrpRS subsites generates a partially assembled state similar to those observed in molecular simulations. Proc.Natl.Acad.Sci.Usa, 106, 2009
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3H8I
| The first X-ray structure of a sulfide:quinone oxidoreductase: Insights into sulfide oxidation mechanism | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, NADH oxidase, PHOSPHATE ION, ... | 著者 | Brito, J.A, Sousa, F.L, Stelter, M, Bandeiras, T.M, Vonrhein, C, Teixeira, M, Pereira, M.M, Archer, M. | 登録日 | 2009-04-29 | 公開日 | 2009-06-02 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Structural and functional insights into sulfide:quinone oxidoreductase. Biochemistry, 48, 2009
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3H8L
| The first X-ray structure of a sulfide:quinone oxidoreductase: insights into sulfide oxidation mechanism | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, NADH oxidase, PHOSPHATE ION, ... | 著者 | Brito, J.A, Sousa, F.L, Stelter, M, Bandeiras, T.M, Vonrhein, C, Teixeira, M, Pereira, M.M, Archer, M. | 登録日 | 2009-04-29 | 公開日 | 2009-06-02 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | Structural and functional insights into sulfide:quinone oxidoreductase. Biochemistry, 48, 2009
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3VF0
| Raver1 in complex with metavinculin L954 deletion mutant | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, Ribonucleoprotein PTB-binding 1, ... | 著者 | Lee, J.H, Vonrhein, C, Bricogne, G, Izard, T. | 登録日 | 2012-01-09 | 公開日 | 2012-07-25 | 最終更新日 | 2012-09-19 | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | 主引用文献 | The Metavinculin Tail Domain Directs Constitutive Interactions with Raver1 and vinculin RNA. J.Mol.Biol., 422, 2012
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4DJ9
| Human vinculin head domain Vh1 (residues 1-258) in complex with the talin vinculin binding site 50 (VBS50, residues 2078-2099) | 分子名称: | Talin-1, Vinculin | 著者 | Yogesha, S.D, Rangarajan, E.S, Vonrhein, C, Bricogne, G, Izard, T. | 登録日 | 2012-02-01 | 公開日 | 2012-02-29 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Crystal structure of vinculin in complex with vinculin binding site 50 (VBS50), the integrin binding site 2 (IBS2) of talin. Protein Sci., 21, 2012
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8ASE
| Crystal structure of Thrombin in complex with macrocycle T3 | 分子名称: | (8~{S},14~{S},18~{E})-8-[(4-chlorophenyl)methyl]-3,21-dithia-7,10,16-triazatricyclo[21.2.2.1^{10,14}]octacosa-1(26),18,23(27),24-tetraene-6,9,15-trione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Chinellato, M, Angelini, A, Nielsen, A, Heinis, C, Cendron, L. | 登録日 | 2022-08-19 | 公開日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Crystal structure of Thrombin in complex with optimized macrocycles T1 and T3 To Be Published
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8ASF
| Crystal structure of Thrombin in complex with macrocycle T1 | 分子名称: | 5-chloranyl-~{N}-[[(9~{S},15~{R})-8,14,17-tris(oxidanylidene)-3,20-dithia-7,13,16-triazatetracyclo[20.2.2.1^{5,7}.1^{9,13}]octacosa-1(25),22(26),23-trien-15-yl]methyl]thiophene-2-carboxamide, Thrombin heavy chain, Thrombin light chain | 著者 | Chinellato, M, Angelini, A, Nielsen, A, Heinis, C, Cendron, L. | 登録日 | 2022-08-19 | 公開日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | 主引用文献 | Crystal structure of Thrombin in complex with optimized macrocycles T1 and T3 To Be Published
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4DW4
| Crystal structure of the glycoprotein Erns from the pestivirus BVDV-1 in complex with 5'-UMP | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, E(rns) glycoprotein, ... | 著者 | Krey, T, Bontems, F, Vonrhein, C, Vaney, M.-C, Bricogne, G, Ruemenapf, T, Rey, F.A. | 登録日 | 2012-02-24 | 公開日 | 2012-05-23 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | Crystal Structure of the Pestivirus Envelope Glycoprotein E(rns) and Mechanistic Analysis of Its Ribonuclease Activity. Structure, 20, 2012
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4DWC
| Crystal structure of the glycoprotein Erns from the pestivirus BVDV-1 in complex with Zn ions | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-D-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Krey, T, Bontems, F, Vonrhein, C, Vaney, M.-C, Bricogne, G, Ruemenapf, T, Rey, F.A. | 登録日 | 2012-02-24 | 公開日 | 2012-05-23 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | 主引用文献 | Crystal Structure of the Pestivirus Envelope Glycoprotein E(rns) and Mechanistic Analysis of Its Ribonuclease Activity. Structure, 20, 2012
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