4GLY

Human urokinase-type plasminogen activator uPA in complex with the two-disulfide bridge peptide UK504

Summary for 4GLY

Entry DOI	10.2210/pdb4gly/pdb
Related	3QN7
Related PRD ID	PRD_001039
Descriptor	Urokinase-type plasminogen activator, BICYCLIC PEPTIDE INHIBITOR UK504, SULFATE ION, ... (8 entities in total)
Functional Keywords	serine protease, chymotrypsin fold, urokinase-type plasminogen activator, bicyclic peptide inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Secreted: P00749
Total number of polymer chains	2
Total formula weight	29962.20
Authors	Buth, S.A.,Leiman, P.G.,Chen, S.,Heinis, C. (deposition date: 2012-08-15, release date: 2013-05-15, Last modification date: 2023-09-13)
Primary citation	Chen, S.,Rentero Rebollo, I.,Buth, S.A.,Morales-Sanfrutos, J.,Touati, J.,Leiman, P.G.,Heinis, C. Bicyclic Peptide Ligands Pulled out of Cysteine-Rich Peptide Libraries. J.Am.Chem.Soc., 135:6562-6569, 2013 Cited by PubMed: 23560397 DOI: 10.1021/ja400461h PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.518 Å)

Structure validation