4MNY

Crystal structure of urokinase-type plasminogen activator (uPA) complexed with bicyclic peptide UK903

Summary for 4MNY

Entry DOI	10.2210/pdb4mny/pdb
Related	2NWN 3QN7 4GLY 4JK5 4JK6 4MNV 4MNW 4MNX
Related PRD ID	PRD_001168
Descriptor	Urokinase-type plasminogen activator chain B, bicyclic peptide UK903, SULFATE ION, ... (7 entities in total)
Functional Keywords	competitive inhibitor, bicyclic peptide, inhibitor, protease, n, n', n''-(benzene-1, 3, 5-triyl)tris(2-bromoacetamide) (tbab) cyclization, extracellular, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Secreted: P00749
Total number of polymer chains	4
Total formula weight	59881.85
Authors	Chen, S.,Pojer, F.,Heinis, C. (deposition date: 2013-09-11, release date: 2014-02-05, Last modification date: 2017-11-15)
Primary citation	Chen, S.,Bertoldo, D.,Angelini, A.,Pojer, F.,Heinis, C. Peptide ligands stabilized by small molecules. Angew.Chem.Int.Ed.Engl., 53:1602-1606, 2014 Cited by PubMed: 24453110 DOI: 10.1002/anie.201309459 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation