4MNY
Crystal structure of urokinase-type plasminogen activator (uPA) complexed with bicyclic peptide UK903
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Urokinase-type plasminogen activator chain B | polymer | 245 | 27586.4 | 2 | UniProt (P00749) Pfam (PF00089) | Homo sapiens (human) | U-plasminogen activator, uPA |
| 2 | C, D (C, D) | bicyclic peptide UK903 | polymer | 14 | 1390.7 | 2 | BIRD (PRD_001168) | ||
| 3 | E, F, K, L (A, B) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 4 | G, H, M, N, P (A, B) | ACETATE ION | non-polymer | 59.0 | 5 | Chemie (ACT) | |||
| 5 | I, J, O (A, B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 6 | Q, R (C, D) | N,N',N''-benzene-1,3,5-triyltris(2-bromoacetamide) | non-polymer | 486.0 | 2 | BIRD (PRD_001168) Chemie (29O) | |||
| 7 | S, T, U, V (A, B, C, D) | water | water | 18.0 | 429 | Chemie (HOH) |
Sequence modifications
A, B: 16 - 242 (UniProt: P00749)
| PDB | External Database | Details |
|---|---|---|
| Ala 122 | Cys 299 | engineered mutation |
| Gln 145 | Asn 322 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 57954.2 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1927.7 | |
| All* | Total formula weight | 59881.8 |
