7NR8
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![BU of 7nr8 by Molmil](/molmil-images/mine/7nr8) | Discovery of ASTX029, a clinical candidate which modulates the phosphorylation and catalytic activity of ERK1/2 | 分子名称: | (2~{R})-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]-~{N}-[(1~{S})-1-[6-(4-methylpiperazin-1-yl)pyridin-2-yl]-2-oxidanyl-ethyl]propanamide, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ... | 著者 | O'Reilly, M, Cleasby, A. | 登録日 | 2021-03-03 | 公開日 | 2021-10-06 | 実験手法 | X-RAY DIFFRACTION (1.627 Å) | 主引用文献 | Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J.Med.Chem., 64, 2021
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7NR5
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![BU of 7nr5 by Molmil](/molmil-images/mine/7nr5) | Discovery of ASTX029, a clinical candidate which modulates the phosphorylation and catalytic activity of ERK1/2 | 分子名称: | (2~{R})-2-[5-[5-chloranyl-2-[(2-methyl-1,2,3-triazol-4-yl)amino]pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]-~{N}-[(1~{S})-1-(3-fluoranyl-5-methoxy-phenyl)-2-oxidanyl-ethyl]propanamide, Mitogen-activated protein kinase 1, SULFATE ION | 著者 | O'Reilly, M, Cleasby, A. | 登録日 | 2021-03-03 | 公開日 | 2021-10-06 | 実験手法 | X-RAY DIFFRACTION (1.766 Å) | 主引用文献 | Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J.Med.Chem., 64, 2021
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5LY9
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![BU of 5ly9 by Molmil](/molmil-images/mine/5ly9) | Structure of MITat 1.1 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, Variant surface glycoprotein MITAT 1.1, ... | 著者 | Schaefer, C, Bartossek, T, Jones, N, Kuper, J, Kisker, C, Engstler, M. | 登録日 | 2016-09-26 | 公開日 | 2017-09-20 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structural basis for the shielding function of the dynamic trypanosome variant surface glycoprotein coat. Nat Microbiol, 2, 2017
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6MT1
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6JPP
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![BU of 6jpp by Molmil](/molmil-images/mine/6jpp) | |
6MT2
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7BGU
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![BU of 7bgu by Molmil](/molmil-images/mine/7bgu) | Mason-Pfizer Monkey Virus Protease mutant C7A/D26N/C106A in complex with peptidomimetic inhibitor | 分子名称: | Gag-Pro-Pol polyprotein, PENTAETHYLENE GLYCOL, peptidomimetic inhibitor | 著者 | Wosicki, S, Gilski, M, Kazmierczyk, M, Jaskolski, M, Zabranska, H, Pichova, I. | 登録日 | 2021-01-08 | 公開日 | 2021-12-15 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.433 Å) | 主引用文献 | Crystal structures of inhibitor complexes of M-PMV protease with visible flap loops. Protein Sci., 30, 2021
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7ONT
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![BU of 7ont by Molmil](/molmil-images/mine/7ont) | PARP1 catalytic domain in complex with a selective pyridine carboxamide-based inhibitor (compound 22) | 分子名称: | 5-[4-[(3-ethyl-2-oxidanylidene-1~{H}-quinolin-7-yl)methyl]piperazin-1-yl]-~{N}-methyl-pyridine-2-carboxamide, Poly [ADP-ribose] polymerase 1, SULFATE ION | 著者 | Schimpl, M, Balazs, A, Barratt, D, Bista, M, Chuba, M, Degorce, S.L, Di Fruscia, P, Embrey, K, Ghosh, A, Gill, S, Gunnarsson, A, Hande, S, Hemsley, P, Heightman, T.D, Illuzzi, G, Lane, J, Larner, C, Leo, E, Madin, A, Martin, S, McWilliams, L, Orme, J, Pachl, F, Packer, M.J, Pike, A, Staniszewska, A.D, Talbot, V, Underwood, E, Varnes, G.J, Zhang, A, Zheng, X, Johannes, J.W. | 登録日 | 2021-05-25 | 公開日 | 2021-09-15 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.853 Å) | 主引用文献 | Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}- N -methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs. J.Med.Chem., 64, 2021
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6JLO
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![BU of 6jlo by Molmil](/molmil-images/mine/6jlo) | XFEL structure of cyanobacterial photosystem II (2F state, dataset2) | 分子名称: | 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, ... | 著者 | Suga, M, Shen, J.R. | 登録日 | 2019-03-06 | 公開日 | 2019-10-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | An oxyl/oxo mechanism for oxygen-oxygen coupling in PSII revealed by an x-ray free-electron laser. Science, 366, 2019
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6JLL
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![BU of 6jll by Molmil](/molmil-images/mine/6jll) | XFEL structure of cyanobacterial photosystem II (2F state, dataset1) | 分子名称: | 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, ... | 著者 | Suga, M, Shen, J.R. | 登録日 | 2019-03-06 | 公開日 | 2019-10-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | An oxyl/oxo mechanism for oxygen-oxygen coupling in PSII revealed by an x-ray free-electron laser. Science, 366, 2019
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7QQE
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![BU of 7qqe by Molmil](/molmil-images/mine/7qqe) | Nuclear factor one X - NFIX in P41212 | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Nuclear factor 1 X-type, ZINC ION | 著者 | Lapi, M, Chaves-Sanjuan, A, Gourlay, L.J, Tiberi, M, Polentarutti, M, Demitri, N, Bais, G, Nardini, M. | 登録日 | 2022-01-07 | 公開日 | 2023-01-18 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Nuclear factor one X - NFIX in P41212 To Be Published
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7QQD
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![BU of 7qqd by Molmil](/molmil-images/mine/7qqd) | Nuclear factor one X - NFIX in P21 | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, NFI binding site (forward), NFI binding site (reverse), ... | 著者 | Lapi, M, Chaves-Sanjuan, A, Gourlay, L.J, Tiberi, M, Polentarutti, M, Demitri, N, Bais, G, Nardini, M. | 登録日 | 2022-01-07 | 公開日 | 2023-01-18 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Nuclear factor one X - NFIX in P41212 To Be Published
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7QRM
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![BU of 7qrm by Molmil](/molmil-images/mine/7qrm) | Cryo-EM structure of catalytically active Spinacia oleracea cytochrome b6f in complex with endogenous plastoquinones at 2.7 A resolution | 分子名称: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 2,3-DIMETHYL-5-(3,7,11,15,19,23,27,31,35-NONAMETHYL-2,6,10,14,18,22,26,30,34-HEXATRIACONTANONAENYL-2,5-CYCLOHEXADIENE-1,4-DIONE-2,3-DIMETHYL-5-SOLANESYL-1,4-BENZOQUINONE, ... | 著者 | Sarewicz, M, Szwalec, M, Indyka, P, Rawski, M, Pintscher, S, Pietras, R, Mielecki, B, Jaciuk, M, Glatt, S, Osyczka, A. | 登録日 | 2022-01-11 | 公開日 | 2023-01-25 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | High-resolution cryo-EM structures of plant cytochrome b 6 f at work. Sci Adv, 9, 2023
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8JZS
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![BU of 8jzs by Molmil](/molmil-images/mine/8jzs) | Outward-facing SLC15A4 dimer | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, lysosomal transporter | 著者 | Zhang, S.S, Chen, X.D, Xie, M. | 登録日 | 2023-07-06 | 公開日 | 2023-09-27 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling. Nat Commun, 14, 2023
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8JZU
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![BU of 8jzu by Molmil](/molmil-images/mine/8jzu) | SLC15A4_TASL complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, TLR adapter,Green fluorescent protein, TSLAA-EGPF tag fusion protein | 著者 | Zhang, S.S, Chen, X.D, Xie, M. | 登録日 | 2023-07-06 | 公開日 | 2023-09-27 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling. Nat Commun, 14, 2023
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7OLY
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![BU of 7oly by Molmil](/molmil-images/mine/7oly) | Structure of activin A in complex with an ActRIIB-Alk4 fusion reveal insight into activin receptor interactions | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Activin receptor type-1B, ... | 著者 | Hakansson, M, Rose, N.C, Castonguay, R, Logan, D.T, Krishnan, L. | 登録日 | 2021-05-20 | 公開日 | 2022-02-23 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.265 Å) | 主引用文献 | Structures of activin ligand traps using natural sets of type I and type II TGF beta receptors. Iscience, 25, 2022
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8JZR
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![BU of 8jzr by Molmil](/molmil-images/mine/8jzr) | Outward_facing SLC15A4 monomer | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, lysosomal transporter,ALFA tag | 著者 | Zhang, S.S, Chen, X.D, Xie, M. | 登録日 | 2023-07-06 | 公開日 | 2023-09-27 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | 主引用文献 | Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling. Nat Commun, 14, 2023
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6TRJ
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![BU of 6trj by Molmil](/molmil-images/mine/6trj) | LEDGF/p75 IBD dimer | 分子名称: | PC4 and SFRS1-interacting protein | 著者 | Kugler, M, Brynda, J. | 登録日 | 2019-12-19 | 公開日 | 2020-09-09 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Fine-tuning of the LEDGF/p75 interaction network by dimerization Structure
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8B75
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8KCM
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![BU of 8kcm by Molmil](/molmil-images/mine/8kcm) | MmCPDII-DNA complex containing low-dosage, light induced repaired DNA. | 分子名称: | Deoxyribodipyrimidine photo-lyase, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | 著者 | Maestre-Reyna, M, Wang, P.-H, Nango, E, Hosokawa, Y, Saft, M, Furrer, A, Yang, C.-H, Ngura Putu, E.P.G, Wu, W.-J, Emmerich, H.-J, Engilberge, S, Caramello, N, Wranik, M, Glover, H.L, Franz-Badur, S, Wu, H.-Y, Lee, C.-C, Huang, W.-C, Huang, K.-F, Chang, Y.-K, Liao, J.-H, Weng, J.-H, Gad, W, Chang, C.-W, Pang, A.H, Gashi, D, Beale, E, Ozerov, D, Milne, C, Cirelli, C, Bacellar, C, Sugahara, M, Owada, S, Joti, Y, Yamashita, A, Tanaka, R, Tanaka, T, Luo, F.J, Tono, K, Kiontke, S, Spadaccini, R, Royant, A, Yamamoto, J, Iwata, S, Standfuss, J, Essen, L.-O, Bessho, Y, Tsai, M.-D. | 登録日 | 2023-08-08 | 公開日 | 2023-11-22 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Visualizing the DNA repair process by a photolyase at atomic resolution. Science, 382, 2023
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8SUV
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![BU of 8suv by Molmil](/molmil-images/mine/8suv) | CHIP-TPR in complex with the C-terminus of CHIC2 | 分子名称: | Cysteine-rich hydrophobic domain-containing protein 2, E3 ubiquitin-protein ligase CHIP, SULFATE ION | 著者 | Cupo, A.R, McDermott, L.E, DeSilva, A.R, Callahan, M, Nix, J.C, Gestwicki, J.E, Page, R.C. | 登録日 | 2023-05-13 | 公開日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Interaction with the membrane-anchored protein CHIC2 constrains the ubiquitin ligase activity of CHIP Biorxiv, 2023
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7OTC
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![BU of 7otc by Molmil](/molmil-images/mine/7otc) | Cryo-EM structure of an Escherichia coli 70S ribosome in complex with elongation factor G and the antibiotic Argyrin B | 分子名称: | 1,4-DIAMINOBUTANE, 16S ribosomal RNA, 23S ribosomal RNA, ... | 著者 | Wieland, M, Koller, T.O, Wilson, D.N. | 登録日 | 2021-06-10 | 公開日 | 2022-05-11 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | The cyclic octapeptide antibiotic argyrin B inhibits translation by trapping EF-G on the ribosome during translocation. Proc.Natl.Acad.Sci.USA, 119, 2022
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7P9O
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![BU of 7p9o by Molmil](/molmil-images/mine/7p9o) | Structure of E.coli RlmJ in complex with a SAM analogue (CA) | 分子名称: | 5'-{[(3S)-3-amino-3-carboxypropyl]amino}-5'-deoxyadenosine, Ribosomal RNA large subunit methyltransferase J | 著者 | Meynier, V, Catala, M, Oerum, S, Barraud, P, Tisne, C. | 登録日 | 2021-07-27 | 公開日 | 2022-05-25 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.095 Å) | 主引用文献 | Synthesis of RNA-cofactor conjugates and structural exploration of RNA recognition by an m6A RNA methyltransferase. Nucleic Acids Res., 50, 2022
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7OMO
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7P8Q
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![BU of 7p8q by Molmil](/molmil-images/mine/7p8q) | Structure of E.coli RlmJ in complex with an RNA conjugate (GA-SAM) | 分子名称: | 5'-{[(3S)-3-amino-3-carboxypropyl](3-aminopropyl)amino}-5'-deoxyadenosine, RNA conjugate (GA-SAM), Ribosomal RNA large subunit methyltransferase J | 著者 | Meynier, V, Catala, M, Oerum, S, Barraud, P, Tisne, C. | 登録日 | 2021-07-23 | 公開日 | 2022-06-01 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.289 Å) | 主引用文献 | Synthesis of RNA-cofactor conjugates and structural exploration of RNA recognition by an m6A RNA methyltransferase. Nucleic Acids Res., 50, 2022
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