7BGU
Mason-Pfizer Monkey Virus Protease mutant C7A/D26N/C106A in complex with peptidomimetic inhibitor
Summary for 7BGU
| Entry DOI | 10.2210/pdb7bgu/pdb |
| Related | 1n49 3hvp 3sqf 4hvp 5kr1 6s1u 6s1v 6s1w |
| Descriptor | Gag-Pro-Pol polyprotein, peptidomimetic inhibitor, PENTAETHYLENE GLYCOL, ... (4 entities in total) |
| Functional Keywords | mason-pfizer monkey virus, m-pmv, retropepsin, active site inhibitor, active site mutant, hydrolase |
| Biological source | Mason-Pfizer monkey virus (MPMV) More |
| Total number of polymer chains | 6 |
| Total formula weight | 53848.02 |
| Authors | Wosicki, S.,Gilski, M.,Kazmierczyk, M.,Jaskolski, M.,Zabranska, H.,Pichova, I. (deposition date: 2021-01-08, release date: 2021-12-15, Last modification date: 2024-11-13) |
| Primary citation | Wosicki, S.,Kazmierczyk, M.,Gilski, M.,Zabranska, H.,Pichova, I.,Jaskolski, M. Crystal structures of inhibitor complexes of M-PMV protease with visible flap loops. Protein Sci., 30:1258-1263, 2021 Cited by PubMed Abstract: Mason-Pfizer monkey virus protease (PR) was crystallized in complex with two pepstatin-based inhibitors in P1 space group. In both crystal structures, the extended flap loops that lock the inhibitor/substrate over the active site, are visible in the electron density either completely or with only small gaps, providing the first observation of the conformation of the flap loops in dimeric complex form of this retropepsin. The H-bond network in the active site (with D26N mutation) differs from that reported for the P2 crystal structures and is similar to a rarely occurring system in HIV-1 PR. PubMed: 33786913DOI: 10.1002/pro.4072 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.433 Å) |
Structure validation
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