4HVP

Structure of complex of synthetic HIV-1 protease with a substrate-based inhibitor at 2.3 Angstroms resolution

Summary for 4HVP

• Entry DOI: 10.2210/pdb4hvp/pdb
• Related PRD ID: PRD_000398
• Descriptor: HIV-1 PROTEASE, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide (3 entities in total)
• Functional Keywords: acid proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus 1
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369
• Total number of polymer chains: 2
• Total formula weight: 22300.26

Authors

Miller, M.,Schneider, J.,Sathyanarayana, B.K.,Toth, M.V.,Marshall, G.R.,Clawson, L.,Selk, L.,Kent, S.B.H.,Wlodawer, A. (deposition date: 1989-08-08, release date: 1990-04-15, Last modification date: 2017-11-29)

• Primary citation: Miller, M.,Schneider, J.,Sathyanarayana, B.K.,Toth, M.V.,Marshall, G.R.,Clawson, L.,Selk, L.,Kent, S.B.,Wlodawer, A.; Structure of complex of synthetic HIV-1 protease with a substrate-based inhibitor at 2.3 A resolution.; Science, 246:1149-1152, 1989; PubMed: 2686029

Experimental method

X-RAY DIFFRACTION (2.3 Å)