5XVA
| Crystal Structure of PAK4 in complex with inhibitor CZH216 | 分子名称: | ETHANOL, Serine/threonine-protein kinase PAK 4, [6-chloranyl-4-[(5-methyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]-[(3R)-3-methylpiperazin-1-yl]methanone | 著者 | Zhao, F, Li, H. | 登録日 | 2017-06-27 | 公開日 | 2018-02-07 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.847 Å) | 主引用文献 | Structure-Based Design of 6-Chloro-4-aminoquinazoline-2-carboxamide Derivatives as Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors. J. Med. Chem., 61, 2018
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5XVG
| Crystal Structure of PAK4 in complex with inhibitor CZH226 | 分子名称: | 1,2-ETHANEDIOL, ETHANOL, Serine/threonine-protein kinase PAK 4, ... | 著者 | Zhao, F, Li, H. | 登録日 | 2017-06-27 | 公開日 | 2018-02-07 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure-Based Design of 6-Chloro-4-aminoquinazoline-2-carboxamide Derivatives as Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors. J. Med. Chem., 61, 2018
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4N5Q
| Crystal structure of the N-terminal ankyrin repeat domain of TRPV3 | 分子名称: | Transient receptor potential cation channel subfamily V member 3 | 著者 | Shi, D.J, Ye, S, Cao, X, Wang, K.W, Zhang, R. | 登録日 | 2013-10-10 | 公開日 | 2014-01-29 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.946 Å) | 主引用文献 | Crystal structure of the N-terminal ankyrin repeat domain of TRPV3 reveals unique conformation of finger 3 loop critical for channel function Protein Cell, 4, 2013
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5XVF
| Crystal Structure of PAK4 in complex with inhibitor CZH062 | 分子名称: | 2-(4-azanylpiperidin-1-yl)-6-chloranyl-N-(1-methylimidazol-4-yl)quinazolin-4-amine, Serine/threonine-protein kinase PAK 4 | 著者 | Zhao, F, Li, H. | 登録日 | 2017-06-27 | 公開日 | 2018-02-07 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.655 Å) | 主引用文献 | Structure-Based Design of 6-Chloro-4-aminoquinazoline-2-carboxamide Derivatives as Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors. J. Med. Chem., 61, 2018
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5AFX
| T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-1238 | 分子名称: | FARNESYL PYROPHOSPHATE SYNTHASE, MAGNESIUM ION, [1-hydroxy-2-(1-nonyl-1H-3lambda~5~-imidazol-3-yl)ethane-1,1-diyl]bis(phosphonic acid) | 著者 | Yang, G, Oldfield, E, No, J.H. | 登録日 | 2015-01-27 | 公開日 | 2015-10-28 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Inhibition of Trypanosoma Brucei Cell Growth by Lipophilic Bisphosphonates: An in Vitro and in Vivo Investigation. Antimicrob.Agents Chemother., 59, 2015
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4DOY
| Crystal structure of Dibenzothiophene desulfurization enzyme C | 分子名称: | Dibenzothiophene desulfurization enzyme C, GLYCEROL | 著者 | Liu, S, Zhang, C, Zhu, D, Gu, L. | 登録日 | 2012-02-12 | 公開日 | 2013-02-13 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.789 Å) | 主引用文献 | Crystal structure of DszC from Rhodococcus sp. XP at 1.79 angstrom Proteins, 82, 2014
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5AHU
| T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-1326 | 分子名称: | FARNESYL PYROPHOSPHATE SYNTHASE, PUTATIVE, MAGNESIUM ION, ... | 著者 | Yang, G, Oldfield, E, No, J.H. | 登録日 | 2015-02-09 | 公開日 | 2015-10-28 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Inhibition of Trypanosoma Brucei Cell Growth by Lipophilic Bisphosphonates: An in Vitro and in Vivo Investigation. Antimicrob.Agents Chemother., 59, 2015
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7E23
| SARS-CoV-2 spike in complex with the CA521 neutralizing antibody Fab (focused refinement on Fab-RBD) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CA521 Heavy Chain, CA521 Light Chain, ... | 著者 | Liu, C, Song, D, Dou, C. | 登録日 | 2021-02-04 | 公開日 | 2021-05-05 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure and function analysis of a potent human neutralizing antibody CA521 FALA against SARS-CoV-2. Commun Biol, 4, 2021
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4XNU
| X-ray structure of Drosophila dopamine transporter in complex with nisoxetine | 分子名称: | CHLORIDE ION, CHOLESTEROL, Integral membrane protein-dopamine transporter, ... | 著者 | Aravind, P, Wang, K, Gouaux, E. | 登録日 | 2015-01-16 | 公開日 | 2015-05-13 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | 主引用文献 | X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine. Nat.Struct.Mol.Biol., 22, 2015
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4XP1
| X-ray structure of Drosophila dopamine transporter bound to neurotransmitter dopamine | 分子名称: | 1,2-ETHANEDIOL, 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Gouaux, E, Penmatsa, A, Wang, K. | 登録日 | 2015-01-16 | 公開日 | 2015-05-06 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | 主引用文献 | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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4XP5
| X-ray structure of Drosophila dopamine transporter bound to cocaine analogue-RTI55 | 分子名称: | 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, Antibody fragment heavy chain-protein, 9D5-heavy chain, ... | 著者 | Gouaux, E, Penmatsa, A, Wang, K. | 登録日 | 2015-01-16 | 公開日 | 2015-05-06 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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4XPB
| X-ray structure of Drosophila dopamine transporter with subsiteB mutations (D121G/S426M) bound to cocaine | 分子名称: | Antibody fragment heavy chain-protein, 9D5-heavy chain, Antibody fragment light chain-protein, ... | 著者 | Aravind, P, Wang, K, Gouaux, E. | 登録日 | 2015-01-16 | 公開日 | 2015-05-13 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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4XPT
| X-ray structure of Drosophila dopamine transporter with subsiteB mutations D121G/S426M and EL2 deletion of 162-201 in complex with substrate analogue 3,4 dichlorophen ethylamine | 分子名称: | 2-(3,4-dichlorophenyl)ethanamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | 著者 | Aravind, P, Wang, K, Gouaux, E. | 登録日 | 2015-01-17 | 公開日 | 2015-05-06 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (3.36 Å) | 主引用文献 | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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4XNX
| X-ray structure of Drosophila dopamine transporter in complex with reboxetine | 分子名称: | (2R)-2-[(R)-(2-ethoxyphenoxy)(phenyl)methyl]morpholine, Antibody fragment heavy chain, CHLORIDE ION, ... | 著者 | Aravind, P, Wang, K, Gouaux, E. | 登録日 | 2015-01-16 | 公開日 | 2015-05-13 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine. Nat.Struct.Mol.Biol., 22, 2015
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4XP6
| X-ray structure of Drosophila dopamine transporter bound to psychostimulant methamphetamine | 分子名称: | (2S)-N-methyl-1-phenylpropan-2-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody fragment heavy chain-protein, ... | 著者 | Aravind, P, Wang, K, Gouaux, E. | 登録日 | 2015-01-16 | 公開日 | 2015-05-13 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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4XP9
| X-ray structure of Drosophila dopamine transporter bound to psychostimulant D-amphetamine | 分子名称: | (2S)-1-phenylpropan-2-amine, 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Aravind, P, Wang, K, Gouaux, E. | 登録日 | 2015-01-16 | 公開日 | 2015-05-06 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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4XPH
| X-ray structure of Drosophila dopamine transporter with subsiteB mutations (D121G/S426M) bound to 3,4dichlorophenethylamine | 分子名称: | 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, 2-(3,4-dichlorophenyl)ethanamine, Antibody fragment heavy chain, ... | 著者 | Penmatsa, A, Wang, K, Gouaux, E. | 登録日 | 2015-01-17 | 公開日 | 2015-05-06 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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4XPA
| X-ray structure of Drosophila dopamine transporter bound to 3,4dichlorophenethylamine | 分子名称: | 2-(3,4-dichlorophenyl)ethanamine, Antibody fragment heavy chain-protein, 9D5-heavy chain, ... | 著者 | Aravind, P, Wang, K, Gouaux, E. | 登録日 | 2015-01-16 | 公開日 | 2015-05-20 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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7E3L
| Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 58G6 heavy chain, 58G6 light chain, ... | 著者 | Guo, H, Li, T, Liu, F, Gao, Y, Ji, X, Yang, H. | 登録日 | 2021-02-09 | 公開日 | 2021-09-15 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants. Nat Commun, 12, 2021
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7E3K
| Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants | 分子名称: | 13G9 heavy chain, 13G9 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Guo, H, Li, T, Liu, F, Gao, Y, Ji, X, Yang, H. | 登録日 | 2021-02-09 | 公開日 | 2021-09-15 | 最終更新日 | 2022-03-02 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants. Nat Commun, 12, 2021
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4XP4
| X-ray structure of Drosophila dopamine transporter in complex with cocaine | 分子名称: | 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, ANTIBODY FRAGMENT HEAVY CHAIN-PROTEIN, 9D5-HEAVY CHAIN, ... | 著者 | Aravind, P, Wang, K, Gouaux, E. | 登録日 | 2015-01-16 | 公開日 | 2015-05-06 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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2FVD
| Cyclin Dependent Kinase 2 (CDK2) with diaminopyrimidine inhibitor | 分子名称: | (4-AMINO-2-{[1-(METHYLSULFONYL)PIPERIDIN-4-YL]AMINO}PYRIMIDIN-5-YL)(2,3-DIFLUORO-6-METHOXYPHENYL)METHANONE, Cell division protein kinase 2 | 著者 | Crowther, R.L, Lukacs, C.M, Kammlott, R.U. | 登録日 | 2006-01-30 | 公開日 | 2006-10-10 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), a potent and selective cyclin-dependent kinase inhibitor with significant in vivo antitumor activity. J.Med.Chem., 49, 2006
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7WSB
| The ternary complex structure of FtmOx1 with a-ketoglutarate and 13-oxo-fumitremorgin B | 分子名称: | 13-Oxofumitremorgin B, 2-OXOGLUTARIC ACID, COBALT (II) ION, ... | 著者 | Wang, J, Wang, X.Y, Wang, Y.Y, Yan, W.P. | 登録日 | 2022-01-28 | 公開日 | 2022-07-06 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.87 Å) | 主引用文献 | Dissecting the Mechanism of the Nonheme Iron Endoperoxidase FtmOx1 Using Substrate Analogues. Jacs Au, 2, 2022
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1OZN
| 1.5A Crystal Structure of the Nogo Receptor Ligand Binding Domain Reveals a Convergent Recognition Scaffold Mediating Inhibition of Myelination | 分子名称: | ACETIC ACID, Reticulon 4 receptor, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | He, X, Bazan, J.F, Park, J.B, McDermott, G, He, Z, Garcia, K.C. | 登録日 | 2003-04-09 | 公開日 | 2003-05-20 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | Structure of the Nogo Receptor Ectodomain. A Recognition module implicated in Myelin Inhibition. Neuron, 38, 2003
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7WTK
| SARS-CoV-2 Omicron variant spike in complex with Fab XGv286 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of XGv286, ... | 著者 | Wang, X, Fu, W. | 登録日 | 2022-02-04 | 公開日 | 2022-12-14 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Selection and structural bases of potent broadly neutralizing antibodies from 3-dose vaccinees that are highly effective against diverse SARS-CoV-2 variants, including Omicron sublineages. Cell Res., 32, 2022
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