2FVD

Cyclin Dependent Kinase 2 (CDK2) with diaminopyrimidine inhibitor

Summary for 2FVD

Entry DOI	10.2210/pdb2fvd/pdb
Descriptor	Cell division protein kinase 2, (4-AMINO-2-{[1-(METHYLSULFONYL)PIPERIDIN-4-YL]AMINO}PYRIMIDIN-5-YL)(2,3-DIFLUORO-6-METHOXYPHENYL)METHANONE (3 entities in total)
Functional Keywords	cdk2 ligand, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	34417.94
Authors	Crowther, R.L.,Lukacs, C.M.,Kammlott, R.U. (deposition date: 2006-01-30, release date: 2006-10-10, Last modification date: 2024-02-14)
Primary citation	Chu, X.J.,DePinto, W.,Bartkovitz, D.,So, S.S.,Vu, B.T.,Packman, K.,Lukacs, C.,Ding, Q.,Jiang, N.,Wang, K.,Goelzer, P.,Yin, X.,Smith, M.A.,Higgins, B.X.,Chen, Y.,Xiang, Q.,Moliterni, J.,Kaplan, G.,Graves, B.,Lovey, A.,Fotouhi, N. Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), a potent and selective cyclin-dependent kinase inhibitor with significant in vivo antitumor activity. J.Med.Chem., 49:6549-6560, 2006 Cited by PubMed: 17064073 DOI: 10.1021/jm0606138 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation