7OR9
| Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-222 and COVOX-278 Fabs | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, COVOX-222 Fab heavy chain, ... | 著者 | Zhou, D, Ren, J, Stuart, D.I. | 登録日 | 2021-06-04 | 公開日 | 2021-07-07 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | 主引用文献 | Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum. Cell, 184, 2021
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7ORA
| Crystal structure of the T478K mutant receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-45 and COVOX-253 Fabs | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, COVOX-253 Fab heavy chain, ... | 著者 | Zhou, D, Ren, J, Stuart, D.I. | 登録日 | 2021-06-04 | 公開日 | 2021-07-07 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum. Cell, 184, 2021
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6NF0
| Nocturnin with bound NADPH substrate | 分子名称: | CALCIUM ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Nocturnin | 著者 | Estrella, M.A, Du, J, Korennykh, A. | 登録日 | 2018-12-18 | 公開日 | 2019-05-01 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | The metabolites NADP+and NADPH are the targets of the circadian protein Nocturnin (Curled). Nat Commun, 10, 2019
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7DZY
| Spike protein from SARS-CoV2 with Fab fragment of enhancing antibody 2490 | 分子名称: | Fab Heavy chain of enhancing antibody 2490, Fab light chain of enhancing antibody 2490, Spike glycoprotein | 著者 | Liu, Y, Soh, W.T, Li, S, Kishikawa, J, Hirose, M, Kato, T, Standley, D, Okada, M, Arase, H. | 登録日 | 2021-01-26 | 公開日 | 2021-06-02 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies. Cell, 184, 2021
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7DZW
| Apo spike protein from SARS-CoV2 | 分子名称: | Spike glycoprotein | 著者 | Liu, Y, Soh, W.T, Li, S, Kishikawa, J, Hirose, M, Kato, T, Standley, D, Okada, M, Arase, H. | 登録日 | 2021-01-26 | 公開日 | 2021-06-02 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | 主引用文献 | An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies. Cell, 184, 2021
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7DZX
| Spike protein from SARS-CoV2 with Fab fragment of enhancing antibody 8D2 | 分子名称: | Fab Heavy chain of enhancing antibody, Fab light chain of enhancing antibody, Spike glycoprotein | 著者 | Liu, Y, Soh, W.T, Li, S, Kishikawa, J, Hirose, M, Kato, T, Standley, D, Okada, M, Arase, H. | 登録日 | 2021-01-26 | 公開日 | 2021-06-02 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.53 Å) | 主引用文献 | An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies. Cell, 184, 2021
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8PH4
| Co-Crystal structure of the SARS-CoV2 main protease Nsp5 with an Uracil-carrying X77-like inhibitor | 分子名称: | 3C-like proteinase nsp5, DIMETHYL SULFOXIDE, MALONATE ION, ... | 著者 | Barthel, T, Altincekic, N, Jores, N, Wollenhaupt, J, Weiss, M.S, Schwalbe, H. | 登録日 | 2023-06-18 | 公開日 | 2024-01-31 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Targeting the Main Protease (M pro , nsp5) by Growth of Fragment Scaffolds Exploiting Structure-Based Methodologies. Acs Chem.Biol., 19, 2024
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6YQD
| Human histidine triad nucleotide-binding protein 2 (hHINT2) refined to 1.41 A in P212121 space group | 分子名称: | Histidine triad nucleotide-binding protein 2, mitochondrial, POTASSIUM ION | 著者 | Dolot, R.D, Wlodarczyk, A, Bujacz, G.D, Nawrot, B.C. | 登録日 | 2020-04-16 | 公開日 | 2020-04-29 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.407 Å) | 主引用文献 | Biochemical, crystallographic and biophysical characterization of histidine triad nucleotide-binding protein 2 with different ligands including a non-hydrolyzable analog of Ap4A. Biochim Biophys Acta Gen Subj, 1865, 2021
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6YI0
| Human histidine triad nucleotide-binding protein 2 (hHINT2) refined to 1.65 A in P41212 space group | 分子名称: | Histidine triad nucleotide-binding protein 2, mitochondrial, SODIUM ION | 著者 | Dolot, R.D, Wlodarczyk, A, Bujacz, G.D, Nawrot, B.C. | 登録日 | 2020-03-31 | 公開日 | 2020-04-29 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Biochemical, crystallographic and biophysical characterization of histidine triad nucleotide-binding protein 2 with different ligands including a non-hydrolyzable analog of Ap4A. Biochim Biophys Acta Gen Subj, 1865, 2021
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8FCZ
| Crystal structure of ground-state rhodopsin in complex with a nanobody | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody Nb2, ... | 著者 | Salom, D, Palczewski, K, Kiser, P.D. | 登録日 | 2022-12-01 | 公開日 | 2023-08-30 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | 主引用文献 | Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain. Nat Commun, 14, 2023
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8ASY
| SARS-CoV-2 Omicron BA.2.75 RBD in complex with ACE2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GLYCEROL, ... | 著者 | Zhou, D, Huo, J, Ren, J, Stuart, D.I. | 登録日 | 2022-08-22 | 公開日 | 2023-01-11 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | A delicate balance between antibody evasion and ACE2 affinity for Omicron BA.2.75. Cell Rep, 42, 2022
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8HNW
| Crystal structure of HpaCas9-sgRNA surveillance complex bound to double-stranded DNA | 分子名称: | CRISPR-associated endonuclease Cas9, Non-target strand, Target strand, ... | 著者 | Sun, W, Cheng, Z, Wang, Y. | 登録日 | 2022-12-08 | 公開日 | 2023-07-19 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (3.41 Å) | 主引用文献 | AcrIIC4 inhibits type II-C Cas9 by preventing R-loop formation. Proc.Natl.Acad.Sci.USA, 120, 2023
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8HNS
| Crystal structure of an anti-CRISPR protein AcrIIC4 in apo form | 分子名称: | GLYCEROL, anti-CRISPR protein AcrIIC4 | 著者 | Sun, W, Cheng, Z, Yang, J, Wang, Y. | 登録日 | 2022-12-08 | 公開日 | 2023-07-19 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | 主引用文献 | AcrIIC4 inhibits type II-C Cas9 by preventing R-loop formation. Proc.Natl.Acad.Sci.USA, 120, 2023
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8HNT
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8HNV
| CryoEM structure of HpaCas9-sgRNA-dsDNA in the presence of AcrIIC4 | 分子名称: | CRISPR-associated endonuclease Cas9, anti-CRISPR protein AcrIIC4, non-target strand, ... | 著者 | Sun, W, Cheng, Z, Wang, J, Yang, X, Wang, Y. | 登録日 | 2022-12-08 | 公開日 | 2023-07-19 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | AcrIIC4 inhibits type II-C Cas9 by preventing R-loop formation. Proc.Natl.Acad.Sci.USA, 120, 2023
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8FD1
| Crystal structure of photoactivated rhodopsin in complex with a nanobody | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody Nb2, ... | 著者 | Salom, D, Palczewski, K, Kiser, P.D. | 登録日 | 2022-12-01 | 公開日 | 2023-08-30 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (4.25 Å) | 主引用文献 | Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain. Nat Commun, 14, 2023
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8FD0
| Crystal structure of bovine rod opsin in complex with a nanobody | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody Nb2, ... | 著者 | Salom, D, Palczewski, K, Kiser, P.D. | 登録日 | 2022-12-01 | 公開日 | 2023-08-30 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.71 Å) | 主引用文献 | Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain. Nat Commun, 14, 2023
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7ZFE
| SARS-CoV-2 Omicron RBD in complex with Omi-32 Fab and nanobody C1 | 分子名称: | Nanobody C1, Omi-32 heavy chain, Omi-32 light chain, ... | 著者 | Zhou, D, Huo, J, Ren, J, Stuart, D.I. | 登録日 | 2022-04-01 | 公開日 | 2022-06-01 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Potent cross-reactive antibodies following Omicron breakthrough in vaccinees. Cell, 185, 2022
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7ZFD
| SARS-CoV-2 Omicron RBD in complex with Omi-25 Fab | 分子名称: | Omi-25 heavy chain, Omi-25 light chain, Spike protein S1 | 著者 | Zhou, D, Huo, J, Ren, J, Stuart, D.I. | 登録日 | 2022-04-01 | 公開日 | 2022-06-01 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.39 Å) | 主引用文献 | Potent cross-reactive antibodies following Omicron breakthrough in vaccinees. Cell, 185, 2022
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7ZFF
| Omi-42 Fab | 分子名称: | GLYCEROL, Omi-42 Heavy chain, Omi-42 light chain | 著者 | Zhou, D, Huo, J, Ren, J, Stuart, D.I. | 登録日 | 2022-04-01 | 公開日 | 2022-06-01 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | 主引用文献 | Potent cross-reactive antibodies following Omicron breakthrough in vaccinees. Cell, 185, 2022
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7ZF6
| Omi-12 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CITRIC ACID, GLYCEROL, ... | 著者 | Zhou, D, Huo, J, Ren, J, Stuart, D.I. | 登録日 | 2022-04-01 | 公開日 | 2022-06-01 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Potent cross-reactive antibodies following Omicron breakthrough in vaccinees. Cell, 185, 2022
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7ZFC
| SARS-CoV-2 Beta RBD in complex with nanobody C1, Omi-18 and Omi-31 Fabs | 分子名称: | Nanobody C1, Omi-18 heavy chain, Omi-18 light chain, ... | 著者 | Zhou, D, Huo, J, Ren, J, Stuart, D.I. | 登録日 | 2022-04-01 | 公開日 | 2022-06-01 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.24 Å) | 主引用文献 | Potent cross-reactive antibodies following Omicron breakthrough in vaccinees. Cell, 185, 2022
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7ZF8
| SARS-CoV-2 Omicron BA.2 RBD in complex with COVOX-150 Fab | 分子名称: | COVOX-150 heavy chain, COVOX-150 light chain, Spike protein S1 | 著者 | Zhou, D, Huo, J, Ren, J, Stuart, D.I. | 登録日 | 2022-04-01 | 公開日 | 2022-06-01 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Potent cross-reactive antibodies following Omicron breakthrough in vaccinees. Cell, 185, 2022
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7ZFB
| SARS-CoV-2 Omicron RBD in complex with nanobody C1, Omi-18 and Omi-31 Fabs | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody C1, Omi-18 heavy chain, ... | 著者 | Zhou, D, Huo, J, Ren, J, Stuart, D.I. | 登録日 | 2022-04-01 | 公開日 | 2022-06-01 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.08 Å) | 主引用文献 | Potent cross-reactive antibodies following Omicron breakthrough in vaccinees. Cell, 185, 2022
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7ZF9
| SARS-CoV-2 Omicron BA.2 RBD in complex with COVOX-150 Fab (P21) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, COVOX-150 heavy chain, COVOX-150 light chain, ... | 著者 | Zhou, D, Huo, J, Ren, J, Stuart, D.I. | 登録日 | 2022-04-01 | 公開日 | 2022-06-01 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Potent cross-reactive antibodies following Omicron breakthrough in vaccinees. Cell, 185, 2022
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