8ASY

SARS-CoV-2 Omicron BA.2.75 RBD in complex with ACE2

8ASY の概要

• エントリーDOI: 10.2210/pdb8asy/pdb
• 分子名称: Processed angiotensin-converting enzyme 2, Spike protein S1, GLYCEROL, ... (6 entities in total)
• 機能のキーワード: sars cov-2, omicron, ba.2.75, ace2, complex, spike, rbd, viral protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 97912.20

構造登録者

Zhou, D.,Huo, J.,Ren, J.,Stuart, D.I. (登録日: 2022-08-22, 公開日: 2023-01-11, 最終更新日: 2024-10-23)

主引用文献

Huo, J.,Dijokaite-Guraliuc, A.,Liu, C.,Zhou, D.,Ginn, H.M.,Das, R.,Supasa, P.,Selvaraj, M.,Nutalai, R.,Tuekprakhon, A.,Duyvesteyn, H.M.E.,Mentzer, A.J.,Skelly, D.,Ritter, T.G.,Amini, A.,Bibi, S.,Adele, S.,Johnson, S.A.,Paterson, N.G.,Williams, M.A.,Hall, D.R.,Plowright, M.,Newman, T.A.H.,Hornsby, H.,de Silva, T.I.,Temperton, N.,Klenerman, P.,Barnes, E.,Dunachie, S.J.,Pollard, A.J.,Lambe, T.,Goulder, P.,Fry, E.E.,Mongkolsapaya, J.,Ren, J.,Stuart, D.I.,Screaton, G.R.
A delicate balance between antibody evasion and ACE2 affinity for Omicron BA.2.75.
Cell Rep, 42:111903-111903, 2022

PubMed Abstract: Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have caused successive global waves of infection. These variants, with multiple mutations in the spike protein, are thought to facilitate escape from natural and vaccine-induced immunity and often increase in affinity for ACE2. The latest variant to cause concern is BA.2.75, identified in India where it is now the dominant strain, with evidence of wider dissemination. BA.2.75 is derived from BA.2 and contains four additional mutations in the receptor-binding domain (RBD). Here, we perform an antigenic and biophysical characterization of BA.2.75, revealing an interesting balance between humoral evasion and ACE2 receptor affinity. ACE2 affinity for BA.2.75 is increased 9-fold compared with BA.2; there is also evidence of escape of BA.2.75 from immune serum, particularly that induced by Delta infection, which may explain the rapid spread in India, where where there is a high background of Delta infection. ACE2 affinity appears to be prioritized over greater escape.

PubMed: 36586406
DOI: 10.1016/j.celrep.2022.111903

実験手法

X-RAY DIFFRACTION (2.85 Å)