8ASY

SARS-CoV-2 Omicron BA.2.75 RBD in complex with ACE2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Processed angiotensin-converting enzyme 2	polymer	604	70139.8	1	UniProt (Q9BYF1) Pfam (PF01401)	Homo sapiens (human)
2	B (B)	Spike protein S1	polymer	219	25154.4	1	UniProt (P0DTC2) Pfam (PF09408)	Homo sapiens (human)
3	C, E, K, M, N... (A, B)	GLYCEROL	non-polymer		92.1	12	Chemie (GOL)
4	D, F, G, H, I... (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG)
5	L (A)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
6	R (A)	TRIETHYLENE GLYCOL	non-polymer		150.2	1	Chemie (PGE)

Sequence modifications

A: 19 - 615 (UniProt: Q9BYF1)

PDB	External Database	Details
Arg 616	-	expression tag
His 617	-	expression tag
His 618	-	expression tag
His 619	-	expression tag
His 620	-	expression tag
His 621	-	expression tag
His 622	-	expression tag

B: 333 - 526 (UniProt: P0DTC2)

PDB	External Database	Details
His 339	Gly 339	variant
Phe 371	Ser 371	variant
Pro 373	Ser 373	variant
Phe 375	Ser 375	variant
Ala 376	Thr 376	variant
Asn 405	Asp 405	variant
Ser 408	Arg 408	variant
Asn 417	Lys 417	variant
Lys 440	Asn 440	variant
Ser 446	Gly 446	variant
Lys 460	Asn 460	variant
Asn 477	Ser 477	variant
Lys 478	Thr 478	variant
Ala 484	Glu 484	variant
Arg 498	Gln 498	variant
Tyr 501	Asn 501	variant
His 505	Tyr 505	variant
Lys 527	-	expression tag
Lys 528	-	expression tag
Ser 529	-	expression tag
Leu 530	-	expression tag
Leu 531	-	expression tag
Asn 532	-	expression tag
Asp 533	-	expression tag
Ile 534	-	expression tag
Phe 535	-	expression tag
Glu 536	-	expression tag
Ala 537	-	expression tag
Gln 538	-	expression tag
Lys 539	-	expression tag
Ile 540	-	expression tag
Glu 541	-	expression tag
Trp 542	-	expression tag
His 543	-	expression tag
Glu 544	-	expression tag
Lys 545	-	expression tag
His 546	-	expression tag
His 547	-	expression tag
His 548	-	expression tag
His 549	-	expression tag
His 550	-	expression tag
His 551	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	95294.2
Non-Polymers*	Number of molecules	20
	Total formula weight	2618.0
All*	Total formula weight	97912.2

*Water molecules are not included.