8FCZ

Crystal structure of ground-state rhodopsin in complex with a nanobody

Summary for 8FCZ

Entry DOI	10.2210/pdb8fcz/pdb
Descriptor	Rhodopsin, Nanobody Nb2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	transmembrane protein, gpcr, nanobody, retinal, membrane protein
Biological source	Lama glama (llama) More
Total number of polymer chains	4
Total formula weight	109366.43
Authors	Salom, D.,Palczewski, K.,Kiser, P.D. (deposition date: 2022-12-01, release date: 2023-08-30, Last modification date: 2024-02-28)
Primary citation	Wu, A.,Salom, D.,Hong, J.D.,Tworak, A.,Watanabe, K.,Pardon, E.,Steyaert, J.,Kandori, H.,Katayama, K.,Kiser, P.D.,Palczewski, K. Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain. Nat Commun, 14:5209-5209, 2023 Cited by PubMed: 37626045 DOI: 10.1038/s41467-023-40911-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.7 Å)

Structure validation