8JWO
 
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8JWM
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8JWK
 | | The second purified state crystal structure of AKRtyl | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Aldo/keto reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Lin, S, Dai, S, Xiao, Z. | | 登録日 | 2023-06-29 | | 公開日 | 2024-04-10 | | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | | 主引用文献 | A three-level regulatory mechanism of the aldo-keto reductase subfamily AKR12D.
Nat Commun, 15, 2024
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8JWN
 | | Crystal structure of AKRtyl-NADPH complex | | 分子名称: | Aldo/keto reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Lin, S, Dai, S, Xiao, Z. | | 登録日 | 2023-06-29 | | 公開日 | 2024-04-10 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | A three-level regulatory mechanism of the aldo-keto reductase subfamily AKR12D.
Nat Commun, 15, 2024
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6CDS
 | | Human neurofibromin 2/merlin/schwannomin residues 1-339 in complex with PIP2 | | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Merlin, ... | | 著者 | Chinthalapudi, K, Sharff, A.J, Bricogne, G, Izard, T. | | 登録日 | 2018-02-09 | | 公開日 | 2018-07-18 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | | 主引用文献 | Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2.
Nat Commun, 9, 2018
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5WQT
 | | Structure of a protein involved in pyroptosis | | 分子名称: | CITRIC ACID, GLYCEROL, Gasdermin-D | | 著者 | Kuang, S, Li, J. | | 登録日 | 2016-11-28 | | 公開日 | 2017-10-04 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | | 主引用文献 | Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6CKV
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1EFN
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7KM5
 | | Crystal structure of SARS-CoV-2 RBD complexed with Nanosota-1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Spike protein S1, ... | | 著者 | Ye, G, Shi, K, Aihara, H, Li, F. | | 登録日 | 2020-11-02 | | 公開日 | 2021-08-04 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | | 主引用文献 | The development of Nanosota - 1 as anti-SARS-CoV-2 nanobody drug candidates.
Elife, 10, 2021
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4P69
 | | Acek (D477A) ICDH complex | | 分子名称: | ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, Isocitrate dehydrogenase [NADP], ... | | 著者 | Jimin, Z, Nan, W, Shu, W, Zongchao, J. | | 登録日 | 2014-03-22 | | 公開日 | 2014-10-08 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | The phosphatase mechanism of bifunctional kinase/phosphatase AceK.
Chem. Commun. (Camb.), 50, 2014
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7ST4
 | | Calcium-saturated jGCaMP8.410.80 | | 分子名称: | CALCIUM ION, GLYCEROL, L(+)-TARTARIC ACID, ... | | 著者 | Zhang, Y, Looger, L.L. | | 登録日 | 2021-11-11 | | 公開日 | 2022-11-16 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Fast and sensitive GCaMP calcium indicators for imaging neural populations
Nature, 615, 2023
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7SQB
 | | PPAR gamma LBD bound to Inverse Agonist SR10221 | | 分子名称: | (2S)-2-{5-[(5-{[(1S)-1-(4-tert-butylphenyl)ethyl]carbamoyl}-2,3-dimethyl-1H-indol-1-yl)methyl]-2-chlorophenoxy}propanoic acid, Peroxisome proliferator-activated receptor gamma | | 著者 | Frkic, R.L, Pederick, J.L, Bruning, J.B. | | 登録日 | 2021-11-05 | | 公開日 | 2023-05-10 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | PPAR gamma Corepression Involves Alternate Ligand Conformation and Inflation of H12 Ensembles.
Acs Chem.Biol., 18, 2023
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7SQA
 | | PPAR gamma LBD bound to SR10221 and SMRT corepressor motif | | 分子名称: | (2S)-2-{5-[(5-{[(1S)-1-(4-tert-butylphenyl)ethyl]carbamoyl}-2,3-dimethyl-1H-indol-1-yl)methyl]-2-chlorophenoxy}propanoic acid, Nuclear receptor corepressor 2, Peroxisome proliferator-activated receptor gamma | | 著者 | Frkic, R.L, Pederick, J.L, Bruning, J.B. | | 登録日 | 2021-11-05 | | 公開日 | 2023-05-10 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.499 Å) | | 主引用文献 | PPAR gamma Corepression Involves Alternate Ligand Conformation and Inflation of H12 Ensembles.
Acs Chem.Biol., 18, 2023
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5ID6
 | | Structure of Cpf1/RNA Complex | | 分子名称: | Cpf1, MAGNESIUM ION, RNA (5'-R(P*AP*AP*UP*UP*UP*CP*UP*AP*CP*UP*AP*AP*GP*UP*GP*UP*AP*GP*AP*UP*C)-3') | | 著者 | Dong, D, Ren, K, Qiu, X, Wang, J, Huang, Z. | | 登録日 | 2016-02-24 | | 公開日 | 2016-04-27 | | 最終更新日 | 2016-05-11 | | 実験手法 | X-RAY DIFFRACTION (2.382 Å) | | 主引用文献 | The crystal structure of Cpf1 in complex with CRISPR RNA
Nature, 532, 2016
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2LK4
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3EAA
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7YH8
 | | Crystal structure of a heterochiral protein complex | | 分子名称: | D-Pep-1, L-19437 | | 著者 | Liang, M, Li, S, Wang, T, Liu, L, Lu, P. | | 登録日 | 2022-07-13 | | 公開日 | 2023-07-19 | | 最終更新日 | 2024-09-25 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Accurate de novo design of heterochiral protein-protein interactions
Cell Res., 2024
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6JXR
 | | Structure of human T cell receptor-CD3 complex | | 分子名称: | T cell receptor alpha variable 12-3,Possible J 11 gene segment,T cell receptor alpha constant, T cell receptor beta variable 6-5,M1-specific T cell receptor beta chain,T cell receptor beta constant 2, T-cell surface glycoprotein CD3 delta chain, ... | | 著者 | Dong, D, Zheng, L, Lin, J, Zhu, Y, Li, N, Zhang, B, Xie, S, Zheng, J, Wang, Y, Gao, N, Huang, Z. | | 登録日 | 2019-04-24 | | 公開日 | 2019-09-11 | | 最終更新日 | 2020-09-16 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural basis of assembly of the human T cell receptor-CD3 complex.
Nature, 573, 2019
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5X0R
 | | Crystal Structure of PXR LBD Complexed with SJB7 | | 分子名称: | 4-[(4-tert-butylphenyl)sulfonyl]-1-(2,4-dimethoxy-5-methylphenyl)-5-methyl-1H-1,2,3-triazole, Nuclear receptor coactivator 1, Nuclear receptor subfamily 1 group I member 2 | | 著者 | Lv, L, Lin, W, Chai, S.C, Zhang, Q, Chen, T. | | 登録日 | 2017-01-23 | | 公開日 | 2017-10-04 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.665 Å) | | 主引用文献 | SPA70 is a potent antagonist of human pregnane X receptor.
Nat Commun, 8, 2017
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3DMS
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3UX9
 | | Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus | | 分子名称: | Interferon alpha-1/13, ScFv antibody | | 著者 | Ouyang, S, Zhao, L.X, Liang, W, Shaw, N, Liu, Z.-J, Liang, M.-F. | | 登録日 | 2011-12-04 | | 公開日 | 2012-02-29 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus
J.Mol.Med., 2012
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4RAY
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4RAZ
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4RB3
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4RB0
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