7SQB

PPAR gamma LBD bound to Inverse Agonist SR10221

Summary for 7SQB

Entry DOI	10.2210/pdb7sqb/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, (2S)-2-{5-[(5-{[(1S)-1-(4-tert-butylphenyl)ethyl]carbamoyl}-2,3-dimethyl-1H-indol-1-yl)methyl]-2-chlorophenoxy}propanoic acid (3 entities in total)
Functional Keywords	inverse agonist, nuclear receptor, ligand binding domain, helix 12, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	34422.74
Authors	Frkic, R.L.,Pederick, J.L.,Bruning, J.B. (deposition date: 2021-11-05, release date: 2023-05-10, Last modification date: 2023-10-25)
Primary citation	Frkic, R.L.,Pederick, J.L.,Horsfall, A.J.,Jovcevski, B.,Crame, E.E.,Kowalczyk, W.,Pukala, T.L.,Chang, M.R.,Zheng, J.,Blayo, A.L.,Abell, A.D.,Kamenecka, T.M.,Harbort, J.S.,Harmer, J.R.,Griffin, P.R.,Bruning, J.B. PPAR gamma Corepression Involves Alternate Ligand Conformation and Inflation of H12 Ensembles. Acs Chem.Biol., 18:1115-1123, 2023 Cited by PubMed: 37146157 DOI: 10.1021/acschembio.2c00917 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation