7SQB

PPAR gamma LBD bound to Inverse Agonist SR10221

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Peroxisome proliferator-activated receptor gamma	polymer	290	33300.5	1	UniProt (P37231) Pfam (PF00104)	Homo sapiens (Human)	PPAR-gamma,Nuclear receptor subfamily 1 group C member 3
2	B, C (A)	(2S)-2-{5-[(5-{[(1S)-1-(4-tert-butylphenyl)ethyl]carbamoyl}-2,3-dimethyl-1H-indol-1-yl)methyl]-2-chlorophenoxy}propanoic acid	non-polymer		561.1	2	Chemie (A8R)
3	D (A)	water	water		18.0	17	Chemie (HOH)

Sequence modifications

A: 203 - 477 (UniProt: P37231)

PDB	External Database	Details
Met 188	-	initiating methionine
Ala 189	-	expression tag
His 190	-	expression tag
His 191	-	expression tag
His 192	-	expression tag
His 193	-	expression tag
His 194	-	expression tag
His 195	-	expression tag
Val 196	-	expression tag
Asp 197	-	expression tag
Asp 198	-	expression tag
Asp 199	-	expression tag
Asp 200	-	expression tag
Lys 201	-	expression tag
Met 202	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	33300.5
Non-Polymers*	Number of molecules	2
	Total formula weight	1122.2
All*	Total formula weight	34422.7

*Water molecules are not included.