7SQB
PPAR gamma LBD bound to Inverse Agonist SR10221
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Peroxisome proliferator-activated receptor gamma | polymer | 290 | 33300.5 | 1 | UniProt (P37231) Pfam (PF00104) | Homo sapiens (Human) | PPAR-gamma,Nuclear receptor subfamily 1 group C member 3 |
| 2 | B, C (A) | (2S)-2-{5-[(5-{[(1S)-1-(4-tert-butylphenyl)ethyl]carbamoyl}-2,3-dimethyl-1H-indol-1-yl)methyl]-2-chlorophenoxy}propanoic acid | non-polymer | 561.1 | 2 | Chemie (A8R) | |||
| 3 | D (A) | water | water | 18.0 | 17 | Chemie (HOH) |
Sequence modifications
A: 203 - 477 (UniProt: P37231)
| PDB | External Database | Details |
|---|---|---|
| Met 188 | - | initiating methionine |
| Ala 189 | - | expression tag |
| His 190 | - | expression tag |
| His 191 | - | expression tag |
| His 192 | - | expression tag |
| His 193 | - | expression tag |
| His 194 | - | expression tag |
| His 195 | - | expression tag |
| Val 196 | - | expression tag |
| Asp 197 | - | expression tag |
| Asp 198 | - | expression tag |
| Asp 199 | - | expression tag |
| Asp 200 | - | expression tag |
| Lys 201 | - | expression tag |
| Met 202 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33300.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1122.2 | |
| All* | Total formula weight | 34422.7 |
