6CDS
Human neurofibromin 2/merlin/schwannomin residues 1-339 in complex with PIP2
Summary for 6CDS
Entry DOI | 10.2210/pdb6cds/pdb |
Descriptor | Merlin, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, PHOSPHATE ION, ... (6 entities in total) |
Functional Keywords | neurofibromin 2, schwannomin, merlin, tumor suppressor protein, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 82346.45 |
Authors | Chinthalapudi, K.,Sharff, A.J.,Bricogne, G.,Izard, T. (deposition date: 2018-02-09, release date: 2018-07-18, Last modification date: 2023-10-04) |
Primary citation | Chinthalapudi, K.,Mandati, V.,Zheng, J.,Sharff, A.J.,Bricogne, G.,Griffin, P.R.,Kissil, J.,Izard, T. Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2. Nat Commun, 9:1338-1338, 2018 Cited by PubMed: 29626191DOI: 10.1038/s41467-018-03648-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.62 Å) |
Structure validation
Download full validation report