6CDS
Human neurofibromin 2/merlin/schwannomin residues 1-339 in complex with PIP2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Merlin | polymer | 339 | 40179.5 | 2 | UniProt (P35240) Pfam (PF09379) Pfam (PF00373) Pfam (PF09380) | Homo sapiens (Human) | Moesin-ezrin-radixin-like protein,Neurofibromin-2,Schwannomerlin,Schwannomin |
| 2 | C, F (A, B) | [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | non-polymer | 746.6 | 2 | Chemie (PIO) | |||
| 3 | D, G (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 4 | E, I (A, B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 5 | H (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | J, K, L, M, N... (A, B) | water | water | 18.0 | 222 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 339 (UniProt: P35240)
| PDB | External Database | Details |
|---|---|---|
| Glu 302 | Gly 302 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 80359.0 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1987.4 | |
| All* | Total formula weight | 82346.4 |
