1T5P
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![BU of 1t5p by Molmil](/molmil-images/mine/1t5p) | Human Heme Oxygenase Oxidation of alpha- and gamma-meso-phenylhemes | 分子名称: | 12-PHENYLHEME, Heme oxygenase 1 | 著者 | Wang, J, Niemevz, F, Lad, L, Buldain, G, Poulos, T.L, Ortiz de Montellano, P.R. | 登録日 | 2004-05-05 | 公開日 | 2004-08-24 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | Human heme oxygenase oxidation of 5- and 15-phenylhemes. J.Biol.Chem., 279, 2004
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1S13
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![BU of 1s13 by Molmil](/molmil-images/mine/1s13) | Human Heme Oxygenase Oxidatition of alpha- and gamma-meso-Phenylhemes | 分子名称: | 2-PHENYLHEME, Heme oxygenase 1 | 著者 | Wang, J, Niemevz, F, Lad, L, Buldain, G, Poulos, T.L, Ortiz de Montellano, P.R. | 登録日 | 2004-01-05 | 公開日 | 2004-08-24 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Human heme oxygenase oxidation of 5- and 15-phenylhemes. J.Biol.Chem., 279, 2004
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7T9U
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![BU of 7t9u by Molmil](/molmil-images/mine/7t9u) | Crystal structure of hSTING with an agonist (SHR169224) | 分子名称: | (3S,4S)-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-4-(prop-2-en-1-yl)-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine-8-carboxamide, CALCIUM ION, Stimulator of interferon genes protein | 著者 | Chowdhury, R, Miller, M. | 登録日 | 2021-12-20 | 公開日 | 2022-12-21 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | 主引用文献 | SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis. Sci Rep, 12, 2022
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7T9V
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![BU of 7t9v by Molmil](/molmil-images/mine/7t9v) | Crystal structure of hSTING with the agonist, SHR171032 | 分子名称: | (3S,4S)-4-(3-{5-carbamoyl-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-7-methoxy-1H-benzimidazol-1-yl}propyl)-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine-8-carboxamide, CALCIUM ION, Stimulator of interferon genes protein | 著者 | Chowdhury, R, Miller, M. | 登録日 | 2021-12-20 | 公開日 | 2022-12-21 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | 主引用文献 | SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis. Sci Rep, 12, 2022
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5YM3
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![BU of 5ym3 by Molmil](/molmil-images/mine/5ym3) | CYP76AH1-4pi from salvia miltiorrhiza | 分子名称: | 4-PHENYL-1H-IMIDAZOLE, Ferruginol synthase, MANGANESE (II) ION, ... | 著者 | Chang, Z. | 登録日 | 2017-10-20 | 公開日 | 2018-10-24 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.601 Å) | 主引用文献 | Crystal structure of CYP76AH1 in 4-PI-bound state from Salvia miltiorrhiza. Biochem.Biophys.Res.Commun., 511, 2019
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6C6N
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6C6R
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![BU of 6c6r by Molmil](/molmil-images/mine/6c6r) | |
6KJZ
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![BU of 6kjz by Molmil](/molmil-images/mine/6kjz) | Crystal structure of PDE4D catalytic domain complexed with compound 1 | 分子名称: | 5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-en-1-yl)-3,4-dihydro-2H,6H-pyrano[3,2-b]xanthen-6-one, MAGNESIUM ION, ZINC ION, ... | 著者 | Huang, Y.-Y, He, X, Luo, H.-B. | 登録日 | 2019-07-23 | 公開日 | 2020-03-18 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.200001 Å) | 主引用文献 | Discovery and Optimization of alpha-Mangostin Derivatives as Novel PDE4 Inhibitors for the Treatment of Vascular Dementia. J.Med.Chem., 63, 2020
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6C6P
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![BU of 6c6p by Molmil](/molmil-images/mine/6c6p) | Human squalene epoxidase (SQLE, squalene monooxygenase) structure with FAD and NB-598 | 分子名称: | (2E)-N-({3-[([3,3'-bithiophen]-5-yl)methoxy]phenyl}methyl)-N-ethyl-6,6-dimethylhept-2-en-4-yn-1-amine, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, FLAVIN-ADENINE DINUCLEOTIDE, ... | 著者 | Padyana, A.K, Jin, L. | 登録日 | 2018-01-19 | 公開日 | 2019-01-16 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase. Nat Commun, 10, 2019
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6KK0
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![BU of 6kk0 by Molmil](/molmil-images/mine/6kk0) | Crystal structure of PDE4D catalytic domain complexed with compound 4e | 分子名称: | 7-[8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)-5-oxidanyl-6-oxidanylidene-pyrano[3,2-b]xanthen-9-yl]oxyheptanoic acid, MAGNESIUM ION, ZINC ION, ... | 著者 | Huang, Y.-Y, He, X, Luo, H.-B. | 登録日 | 2019-07-23 | 公開日 | 2020-03-18 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.20008755 Å) | 主引用文献 | Discovery and Optimization of alpha-Mangostin Derivatives as Novel PDE4 Inhibitors for the Treatment of Vascular Dementia. J.Med.Chem., 63, 2020
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4GMB
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![BU of 4gmb by Molmil](/molmil-images/mine/4gmb) | Crystal structure of human WD repeat domain 5 with compound MM-402 | 分子名称: | MM-402, WD repeat-containing protein 5 | 著者 | Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S. | 登録日 | 2012-08-15 | 公開日 | 2014-02-19 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.781 Å) | 主引用文献 | Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction. J.Med.Chem., 60, 2017
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8U7U
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![BU of 8u7u by Molmil](/molmil-images/mine/8u7u) | Proteasome 20S Core Particle from Beta 3 D205 deletion | 分子名称: | Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, ... | 著者 | Walsh Jr, R.M, Rawson, S, Velez, B, Blickling, M, Razi, A, Hanna, J. | 登録日 | 2023-09-15 | 公開日 | 2024-04-17 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.16 Å) | 主引用文献 | Mechanism of autocatalytic activation during proteasome assembly. Nat.Struct.Mol.Biol., 2024
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8U6Y
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![BU of 8u6y by Molmil](/molmil-images/mine/8u6y) | Preholo-Proteasome from Beta 3 D205 deletion | 分子名称: | Proteasome assembly chaperone 2, Proteasome chaperone 1, Proteasome maturation factor UMP1, ... | 著者 | Walsh Jr, R.M, Rawson, S, Velez, B, Blickling, M, Razi, A, Hanna, J. | 登録日 | 2023-09-14 | 公開日 | 2024-04-17 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Mechanism of autocatalytic activation during proteasome assembly. Nat.Struct.Mol.Biol., 2024
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8J5Z
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![BU of 8j5z by Molmil](/molmil-images/mine/8j5z) | The cryo-EM structure of the TwOSC1 tetramer | 分子名称: | Terpene cyclase/mutase family member, octyl beta-D-glucopyranoside | 著者 | Ma, X, Yuru, T, Yunfeng, L, Jiang, T. | 登録日 | 2023-04-24 | 公開日 | 2023-11-01 | 最終更新日 | 2024-01-03 | 実験手法 | ELECTRON MICROSCOPY (4.75 Å) | 主引用文献 | Structural and Catalytic Insight into the Unique Pentacyclic Triterpene Synthase TwOSC. Angew.Chem.Int.Ed.Engl., 62, 2023
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3WBM
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![BU of 3wbm by Molmil](/molmil-images/mine/3wbm) | Crystal Structure of protein-RNA complex | 分子名称: | DNA/RNA-binding protein Alba 1, RNA (25-MER) | 著者 | Ding, J, Wang, D.C. | 登録日 | 2013-05-20 | 公開日 | 2013-12-11 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Biochemical and structural insights into RNA binding by Ssh10b, a member of the highly conserved Sac10b protein family in Archaea. J.Biol.Chem., 289, 2014
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4RWB
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![BU of 4rwb by Molmil](/molmil-images/mine/4rwb) | Racemic influenza M2-TM crystallized from monoolein lipidic cubic phase | 分子名称: | Matrix protein 2, [(Z)-octadec-9-enyl] (2R)-2,3-bis(oxidanyl)propanoate | 著者 | Mortenson, D.E, Steinkruger, J.D, Kreitler, D.F, Gellman, S.H, Forest, K.T. | 登録日 | 2014-12-02 | 公開日 | 2015-10-14 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | High-resolution structures of a heterochiral coiled coil. Proc.Natl.Acad.Sci.USA, 112, 2015
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4RWC
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![BU of 4rwc by Molmil](/molmil-images/mine/4rwc) | Racemic M2-TM crystallized from racemic detergent | 分子名称: | Matrix protein 2, octyl beta-D-glucopyranoside | 著者 | Mortenson, D.E, Steinkruger, J.D, Kreitler, D.F, Gellman, S.H, Forest, K.T. | 登録日 | 2014-12-02 | 公開日 | 2015-10-14 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | 主引用文献 | High-resolution structures of a heterochiral coiled coil. Proc.Natl.Acad.Sci.USA, 112, 2015
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8KAJ
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8KAI
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![BU of 8kai by Molmil](/molmil-images/mine/8kai) | |
8KAM
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![BU of 8kam by Molmil](/molmil-images/mine/8kam) | |
8KAL
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![BU of 8kal by Molmil](/molmil-images/mine/8kal) | |
8KAK
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8KAH
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8KAG
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![BU of 8kag by Molmil](/molmil-images/mine/8kag) | |
6WNH
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![BU of 6wnh by Molmil](/molmil-images/mine/6wnh) | Menin bound to inhibitor M-808 | 分子名称: | Menin, methyl [(1S,2R)-2-{(1S)-2-(azetidin-1-yl)-1-(3-fluorophenyl)-1-[1-({1-[4-({1-[4-(piperidin-1-yl)butanoyl]azetidin-3-yl}sulfonyl)phenyl]azetidin-3-yl}methyl)piperidin-4-yl]ethyl}cyclopentyl]carbamate, praseodymium triacetate | 著者 | Stuckey, J.A. | 登録日 | 2020-04-22 | 公開日 | 2020-05-13 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin-MLL Interaction with StrongIn VivoAntitumor Activity. J.Med.Chem., 63, 2020
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