7T9V

Crystal structure of hSTING with the agonist, SHR171032

Summary for 7T9V

• Entry DOI: 10.2210/pdb7t9v/pdb
• Descriptor: Stimulator of interferon genes protein, CALCIUM ION, (3S,4S)-4-(3-{5-carbamoyl-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-7-methoxy-1H-benzimidazol-1-yl}propyl)-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine-8-carboxamide, ... (4 entities in total)
• Functional Keywords: agonist, immune system, immune system-inhibitor complex, immune system-agonist complex, immune system/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 46023.67

Authors

Chowdhury, R.,Miller, M. (deposition date: 2021-12-20, release date: 2022-12-21, Last modification date: 2023-10-25)

• Primary citation: Song, C.,Liu, D.,Liu, S.,Li, D.,Horecny, I.,Zhang, X.,Li, P.,Chen, L.,Miller, M.,Chowdhury, R.,Issa, M.,Shen, R.,Yan, Y.,Zhang, F.,Zhang, L.,Zhang, L.,Bai, C.,Feng, J.,Zhuang, L.,Zhang, R.,Li, J.,Wilkinson, H.,Liu, J.,Tao, W.; SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis.; Sci Rep, 12:8579-8579, 2022; PubMed: 35595822; DOI: 10.1038/s41598-022-12449-1

Experimental method

X-RAY DIFFRACTION (2.68 Å)