7T9V
Crystal structure of hSTING with the agonist, SHR171032
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Stimulator of interferon genes protein | polymer | 198 | 22603.4 | 2 | UniProt (Q86WV6) Pfam (PF15009) In PDB | Homo sapiens (human) | hSTING,Endoplasmic reticulum interferon stimulator,ERIS,Mediator of IRF3 activation,hMITA,Transmembrane protein 173 |
| 2 | A, B | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 3 | A | (3S,4S)-4-(3-{5-carbamoyl-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-7-methoxy-1H-benzimidazol-1-yl}propyl)-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine-8-carboxamide | non-polymer | 736.8 | 1 | Chemie (GC0) | |||
| 4 | water | water | 18.0 | 64 | Chemie (HOH) |
Sequence modifications
A, B: 149 - 345 (UniProt: Q86WV6)
| PDB | External Database | Details |
|---|---|---|
| Met 148 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 45206.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 816.9 | |
| All* | Total formula weight | 46023.7 |
