Human squalene epoxidase (SQLE, squalene monooxygenase) structure with FAD and Cmpd-4"

Summary for 6C6N

Related6C6P 6C6R
DescriptorSqualene monooxygenase, GLYCEROL, SULFATE ION, ... (7 entities in total)
Functional Keywordscholesterol synthesis pathway, sqle, erg1, fad-dependent monooxygenase, squalene hydroxylase, squalene-2, 3-epoxidase, flavoprotein, oxidoreductase-oxidoreductase inhibitor complex, flavoprotein-inhibitor complex, flavoprotein/inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight109122.65
Padyana, A.K.,Jin, L. (deposition date: 2018-01-19, release date: 2019-01-16, Last modification date: 2019-01-23)
Primary citation
Padyana, A.K.,Gross, S.,Jin, L.,Cianchetta, G.,Narayanaswamy, R.,Wang, F.,Wang, R.,Fang, C.,Lv, X.,Biller, S.A.,Dang, L.,Mahoney, C.E.,Nagaraja, N.,Pirman, D.,Sui, Z.,Popovici-Muller, J.,Smolen, G.A.
Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase.
Nat Commun, 10:97-97, 2019
PubMed: 30626872 (PDB entries with the same primary citation)
DOI: 10.1038/s41467-018-07928-x
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2202 0.2% 2.0% 5.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6c6n
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Molmil generated image of 6c6n
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Molmil generated image of 6c6n
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